Atypical Chronic Myeloid Leukemia

hematologic malignancy

Identifier: CI-CAN-00001844
Entity page: /cancer/atypical-chronic-myeloid-leukemia ↗
Edges: 114

Neighbours: 2 genes2 variants15 drugs10 trials
Drawn: 29 of 29 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Atypical Chronic Myeloid Leukemia prognostic in …PROGNOSTIC_IN1 of 1
← prognostic in	SETBP1 Exon 4 Mutation	supports	B	Atypical Chronic Myeloid Leukemia	1	Curated	civic	graph →
Atypical Chronic Myeloid Leukemia diagnostic of …DIAGNOSTIC_OF1 of 1
← diagnostic of

Atypical Chronic Myeloid Leukemia associated with …ASSOCIATED_WITH2 of 2
← associated with	CSF3R	supports	B	Atypical Chronic Myeloid Leukemia	1	Curated	civic	graph →
← associated with	SETBP1	supports	B	Atypical Chronic Myeloid Leukemia	1	Curated	civic	graph →

Atypical Chronic Myeloid Leukemia associated with …ASSOCIATED_WITH2 of 2

← associated with

CSF3R

supports

Atypical Chronic Myeloid Leukemia investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 71show all (up to 200)
→ investigated in trials for	Fludarabinesmall molecule 5 trials (0 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Azacitidinesmall molecule 3 trials (2 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumabmonoclonal antibody 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Ruxolitinibsmall molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Sunitinibsmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Carboplatinsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Decitabinesmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Sirolimussmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Venetoclaxsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Vorinostatsmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Abemaciclibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Abirateronesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Afatinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Afliberceptother 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Akt Inhibitor MK2206 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →

Atypical Chronic Myeloid Leukemia studied in …STUDIED_INderived10 of 39show all (up to 200)
→ studied in	NCT06523556Phase 1/Phase 2 · recruiting Axatilimab With or Without Azacitidine for the Treatment of Patients With Advanced Phase Myeloproliferative Neoplasms, Myeloproliferative Neoplasm/Myelodysplastic Syndrome Overlap or High Risk Chronic Myelomonocytic Leukemia · condition mapped ONTOLOGY_EXACT · 39 trials mapped (9 active)	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT03862157Phase 1/Phase 2 · active not recruiting Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia · condition mapped ALIAS · 39 trials mapped (9 active)	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT03289910Phase 2 · active not recruiting Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia · condition mapped ONTOLOGY_EXACT · 39 trials mapped (9 active)	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT05549661Phase 1 · recruiting Onvansertib for the Treatment of Recurrent or Refractory Chronic Myelomonocytic Leukemia and Myelodysplastic Syndrome/MPN Overlap Neoplasms · condition mapped CURATED_BROADER · 39 trials mapped (9 active)	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT03964506early Phase 1 · recruiting Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant · condition mapped ONTOLOGY_EXACT · 39 trials mapped (9 active)	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07468916Phase 2 · not yet recruiting Ropeginterferon Alfa-2b for the Treatment of Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes and Chronic Myelomonocytic Leukemia · condition mapped ONTOLOGY_EXACT · 39 trials mapped (9 active)	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT04761770Phase 2 · active not recruiting Study of a Geriatric Assessment to Plan a Treatment Approach for Older People With Various Blood Disorders · condition mapped ONTOLOGY_EXACT · 39 trials mapped (9 active)	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT01199562active not recruiting Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant · condition mapped ONTOLOGY_EXACT · 39 trials mapped (9 active)	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07238712Phase 2 · recruiting Optimization of Post-transplantation Benadamustine and Cyclophosphamide in Patients With High-risk Myeloid Malignancies and a Partially Mismatched Donor · condition mapped ONTOLOGY_EXACT · 39 trials mapped (9 active)	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT03878524Phase 1 · terminated Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial · condition mapped ALIAS · 39 trials mapped (9 active)	—	—	Atypical Chronic Myeloid Leukemia	1	Observed	clinicaltrials	graph →

Radial view

Every edge, grouped by relationship

Strongest chains