Appendix Carcinoma

subtype

Identifier: CI-CAN-00001817
Entity page: /cancer/appendix-carcinoma ↗
Edges: 62

Neighbours: 6 genes21 drugs10 trials
Drawn: 37 of 37 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Appendix Carcinoma altered in cohorts of …ALTERED_INderived6 of 6
← altered in cohorts of	KRAS 161 / 273 cases (59 %) · ssm · appendiceal_msk_2022	—	—	Appendix Adenocarcinoma	1	Observed	cbioportal	graph →
← altered in cohorts of	GNAS 91 / 273 cases (33 %) · ssm · appendiceal_msk_2022	—	—

Appendix Carcinoma investigated in trials for …INVESTIGATED_IN_TRIALSderived21 of 21show fewer
→ investigated in trials for	Fluorouracilsmall molecule 5 trials (3 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Oxaliplatinsmall molecule 5 trials (2 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Irinotecansmall molecule 4 trials (2 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Leucovorinsmall molecule 4 trials (2 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Mitomycinsmall molecule 4 trials (2 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Atezolizumabmonoclonal antibody 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Capecitabinesmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Cetuximabmonoclonal antibody 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Chemotherapy 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cisplatinsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cobimetinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Dexamethasonesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Doxorubicinsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Erlotinib Hydrochloridesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Hyperthermic Intraperitoneal Chemotherapy 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumabmonoclonal antibody 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal antibody 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Paclitaxelsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Sintilimabmonoclonal antibody 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Thalidomidesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →

Appendix Carcinoma investigated in trials for …INVESTIGATED_IN_TRIALSderived21 of 21show fewer

→ investigated in trials for

Fluorouracilsmall molecule

5 trials (3 active) · roll-up of the cancer and its descendants

—

Appendix Carcinoma

Observed

Appendix Carcinoma studied in …STUDIED_INderived10 of 35show all (up to 200)
→ studied in	NCT07271355Phase 3 · recruiting Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial · condition mapped CURATED_BROADER · 35 trials mapped (16 active)	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03074513Phase 2 · active not recruiting Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors · condition mapped ONTOLOGY_EXACT · 35 trials mapped (16 active)	—	—	Appendix Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07283939NA · recruiting Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays · condition mapped ONTOLOGY_EXACT · 35 trials mapped (16 active)	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07795749Phase 2 · recruiting Ph II Intraperitoneal Paclitaxel + System Therapy in GI Ca w/Peritoneal Carcinomatosis (STOPGAP-B) · condition mapped ALIAS · 35 trials mapped (16 active)	—	—	Appendix Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07658196Phase 1 · recruiting TLR9 Immunotherapy for Peritoneal Carcinomatosis · condition mapped ALIAS · 35 trials mapped (16 active)	—	—	Appendix Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07753824Phase 2 · not yet recruiting A Phase II Study of Ivonescimab Combined With Intraperitoneal Paclitaxel in Patients With High-Grade Metastatic Appendiceal Adenocarcinoma (AA) · condition mapped ALIAS · 35 trials mapped (16 active)	—	—	Appendix Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04329494Phase 1 · recruiting PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer · condition mapped CURATED_BROADER · 35 trials mapped (16 active)	—	—	Appendix Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06399757Phase 1/Phase 2 · active not recruiting A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors · condition mapped ALIAS · 35 trials mapped (16 active)	—	—	Appendix Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06207305Phase 1/Phase 2 · recruiting A Phase I/II Study of Intraperitoneal Paclitaxel in Patients With Metastatic Appendiceal Adenocarcinoma · condition mapped CURATED_BROADER · 35 trials mapped (16 active)	—	—	Appendix Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07587268recruiting Molecular Profiling for Risk Stratification in Appendiceal Cancer · condition mapped ALIAS · 35 trials mapped (16 active)	—	—	Appendix Adenocarcinoma	1	Observed	clinicaltrials	graph →

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