Acute Myeloid Leukemia with NPM1 Mutation

molecular subtype

Identifier: CI-CAN-00008667
Entity page: /cancer/acute-myeloid-leukemia-with-npm1-mutation ↗
Edges: 18

Neighbours: 1 genes1 variants10 drugs6 trials
Drawn: 18 of 18 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Acute Myeloid Leukemia with NPM1 Mutation diagnostic of …DIAGNOSTIC_OF1 of 1
← diagnostic of	NPM1 MUTATIONother 3 source records aggregated	supports	B	Acute Myeloid Leukemia with NPM1 Mutation	3	Curated	civic	graph →
Acute Myeloid Leukemia with NPM1 Mutation associated with …ASSOCIATED_WITH1 of 1

Acute Myeloid Leukemia with NPM1 Mutation investigated in trials for …INVESTIGATED_IN_TRIALSderived10 of 10
→ investigated in trials for	Cytarabinesmall molecule 3 trials (3 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with NPM1 Mutation	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Daunorubicinsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with NPM1 Mutation	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Gilteritinibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with NPM1 Mutation	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Revumenibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with NPM1 Mutation	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Ziftomenibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with NPM1 Mutation	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Azacitidinesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with NPM1 Mutation	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with NPM1 Mutation	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Idarubicinsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with NPM1 Mutation	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Quizartinibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with NPM1 Mutation	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Venetoclaxsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Myeloid Leukemia with NPM1 Mutation	1	Observed	clinicaltrials	graph →

Acute Myeloid Leukemia with NPM1 Mutation studied in …STUDIED_INderived6 of 6
→ studied in	NCT07566585Phase 1 · withdrawn Dose Finding Study to Evaluate the Safety of BSB-2002 in Relapsed or Refractory Acute Myeloid Leukemia (AML) Patients With NPM1 Mutation · condition mapped ALIAS · 6 trials mapped (4 active)	—	—	Acute Myeloid Leukemia with NPM1 Mutation	1	Observed	clinicaltrials	graph →
→ studied in	NCT05886049Phase 1 · recruiting A Phase 1b Study of Menin Inhibitor SNDX- 5613 in Combination With Daunorubicin and Cytarabine in Newly Diagnosed Patients With Acute Myeloid Leukemia and NPM1 Mutated/FLT3 Wildtype or MLL/KMT2A Rearranged or NUP98 Alterations Disease · condition mapped ONTOLOGY_EXACT · 6 trials mapped (4 active)	—	—	Acute Myeloid Leukemia with NPM1 Mutation	1	Observed	clinicaltrials	graph →
→ studied in	NCT06001788Phase 1 · recruiting Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia · condition mapped ALIAS · 6 trials mapped (4 active)	—	—	Acute Myeloid Leukemia with NPM1 Mutation	1	Observed	clinicaltrials	graph →
→ studied in	NCT06222580Phase 1 · recruiting SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation · condition mapped ONTOLOGY_EXACT · 6 trials mapped (4 active)	—	—	Acute Myeloid Leukemia with NPM1 Mutation	1	Observed	clinicaltrials	graph →
→ studied in	NCT05735184Phase 1 · recruiting A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML · condition mapped ALIAS · 6 trials mapped (4 active)	—	—	Acute Myeloid Leukemia with NPM1 Mutation	1	Observed	clinicaltrials	graph →
→ studied in	NCT04689815Phase 2 · unknown Oral Arsenic Trioxide for NPM1-mutated AML · condition mapped ALIAS · 6 trials mapped (4 active)	—	—	Acute Myeloid Leukemia with NPM1 Mutation	1	Observed	clinicaltrials	graph →

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