Gene

TNC

tenascin C

Explore in graph →CI-GENE-00035739HGNC:5318 ENSG00000041982 NCBI 3371 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TNC TNC-L2
(prognostic)	Malignant Pancreatic Neoplasm	Prognostic	B	Supports Poor Outcome	4	submitted	EID9604 In a clinical study including 106 patients, over expression of TNC-L is significantly associated with decreased OS by a multivariate analysis (p = 0.0005). PMID 31463696 · Hagiwara et al., 2020 · Open in CIViC	civic
Gemcitabine	Malignant Pancreatic Neoplasm	Predictive	D	Supports Resistance	4	submitted	EID9603 In an in vitro study, an increased gemcitabine IC50 significantly correlated with increased concentration of TNfnA-D (TNC-L). Resistance reached a platform at 20 ug/ml (p < 0.01). PMID 20686216 · Gong et al., 2010 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (28)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved28 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Skin Cutaneous Melanoma(Broad, Cancer Discov 2014) skcm_broad_brafresist_2012	Cutaneous Melanoma	Ssm	15	78

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.