Gene

SLC12A2

solute carrier family 12 member 2

Explore in graph →CI-GENE-00030916HGNC:10911 ENSG00000064651 NCBI 6558 CIViC Approved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
SLC12A2 OVEREXPRESSION2
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	2	submitted	EID12683 Bumetanide directly inhibits NKCC1 (SLC12A2) with an IC50 of 0.16–0.28 μM in hNKCC1-transfected HEK293 cells, which is substantially more potent than the NKCC1 inhibitor ARN23746 (IC50 ~20 μM) and STS… (full text at CIViC) PMID 34883135 · Löscher et al., 2022 · Open in CIViC	civic
Antisecretory Factor-enriched Egg Yolk Powder Supplement + TemozolomideCombination	GlioblastomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	3	submitted	EID12689 Antisecretory factor (AF) induction by the SPC diet or Salovum in GBM xenografts (GBM43, GBM6) reduced NKCC1-mediated chloride influx, chloride permeability, and blocked regulatory volume increase in …

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Clear Cell Renal Cell Carcinoma (DFCI, Science 2019) ccrcc_dfci_2019	Clear Cell Renal Cell Carcinoma	Ssm	3

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.