Gene
SH2D1A
SH2 domain containing 1A
Explore in graph →CI-GENE-00030518HGNC:10820 ENSG00000183918 NCBI 4068 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (4)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 29337640
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Non-Small Cell Lung Cancer (MSK, J Clin Oncol 2018) nsclc_pd1_msk_2018 | Lung Non-Small Cell Carcinoma | Ssm | 5 | 240 | 2.1% | 155 | cbioportal |
| Sarcoma (UCLA, Cell 2024) sarcoma_ucla_2024 | unmapped | Ssm | 1 | 63 | 1.6% | 196 | cbioportal |
| Breast Cancer (MSK, NPJ Breast Cancer 2019) brca_mskcc_2019 | Invasive Breast Carcinoma | Ssm | 1 | 70 | 1.4% | 187 | cbioportal |
| Hepatocellular Carcinoma (MSK, Clin Cancer Res 2018) hcc_mskimpact_2018 | Hepatocellular Carcinoma | Ssm | 1 | 127 | 0.8% | 191 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.