Gene
PLK2
polo like kinase 2
Explore in graph →CI-GENE-00020145HGNC:19699 ENSG00000145632 NCBI 10769 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (51)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 28007021
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Pediatric Pan-cancer (Columbia U, Genome Med 2016) mixed_pipseq_2017 | unmapped | Ssm | 14 | 103 | 13.6% | 79 | cbioportal |
| Endometrial Carcinoma MSI (MSK, Clin Cancer Res 2022) ucec_ccr_msk_2022 | Endometrial Carcinoma | Ssm | 19 | 181 | 10.5% | 126 | cbioportal |
| Endometrial Carcinoma (MSK, Molecular Oncology 2024) ucs_msk_2024 | Endometrial Carcinoma | Ssm | 7 | 69 | 10.1% | 140 | cbioportal |
| Upper Tract Urothelial Carcinoma PDX (MSK, Nat Commun 2020) utuc_pdx_msk_2019 | Renal Pelvis and Ureter Urothelial Carcinoma | Ssm | 5 | 78 | 6.4% | 104 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.