PLK1

polo like kinase 1

Explore in graph →CI-GENE-00020144HGNC:9077 ENSG00000166851 NCBI 5347 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PLK1 OVEREXPRESSION1
(prognostic)	GlioblastomaCURATED_BROADER	Prognostic	B	Supports Poor Outcome	2	submitted	EID8005 Kaplan-Meier analysis of PLK1 gene expression showed that elevated expression is significantly associated with shorter disease-free survival in GBM (p=9.1e-11). PMID 32180229 · Li et al., 2020 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (1)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved1 cohort row · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Adenocarcinoma (Genentech, Nature 2012) coadread_genentech	Colorectal Adenocarcinoma	Ssm	9	72

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.