PBX1 — gene · CancerIndex

Curated evidence

Clinical evidence (8)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–8 of 8 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PBX1 Fusion8
(diagnostic)	B Acute Lymphoblastic Leukemia with t(1;19)(q23;p13.3); TCF3-PBX1ALIAS	Diagnostic	A	Supports Positive	5	accepted	EID11771 The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours listed TCF3::PBX1 rearrangement in the essential diagnostic criteria for “B-lymphoblastic leukaemia/lymphoma … (full text at CIViC) PMID 35732829 · Alaggio et al., 2022 · Open in CIViC	civic
〃	B Acute Lymphoblastic Leukemia with t(1;19)(q23;p13.3); TCF3-PBX1ALIAS	Diagnostic	B	Supports Positive	4	rejected	EID11715 This is a large cohort study led by St Jude Children's Research Hospital with extensive genome-wide molecular profiles of 2754 children with acute lymphoblastic leukemia(ALL). Consistent with the prof…

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

Data not yet available

No cohort frequency recorded for this gene.

Literature

25 per page, newest first.

pubmedPublishedShowing 1–4 of 4 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.