Gene
PAK1
p21 (RAC1) activated kinase 1
Explore in graph →CI-GENE-00018823HGNC:8590 ENSG00000149269 NCBI 5058 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (24)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 36355783
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022 | Colorectal Adenocarcinoma | Ssm | 7 | 22 | 31.8% | 179 | cbioportal |
| Sarcoma (MSK, 2026) lms_msk_2026 | unmapped | Ssm | 3 | 41 | 7.3% | 126 | cbioportal |
| Upper Tract Urothelial Carcinoma PDX (MSK, Nat Commun 2020) utuc_pdx_msk_2019 | Renal Pelvis and Ureter Urothelial Carcinoma | Ssm | 5 | 76 | 6.6% | 102 | cbioportal |
| Pancreatic Neuroendocrine Tumors (MSK, 2023) panet_msk_erc_2023 | unmapped | Ssm | 2 | 62 | 3.2% | 89 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.