Gene
NOTCH4
notch receptor 4
Explore in graph →CI-GENE-00017014HGNC:7884 ENSG00000204301 NCBI 4855 Cancer geneApproved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (145)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 39499893
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Bladder Urothelial Carcinoma SWOG S1314 Trial (MSK, JCO Precis Oncol 2024) blca_msk_2024 | Bladder Urothelial Carcinoma | Ssm | 8 | 184 | 4.3% | 90 | cbioportal |
| Lung Adenocarcinoma (MSK, J Thorac Oncol 2020) |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.