Gene
NKX2-1
NK2 homeobox 1
Explore in graph →CI-GENE-00016825HGNC:11825 ENSG00000136352 NCBI 7080 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (53)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 36355783
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022 | Colorectal Adenocarcinoma | Ssm | 8 | 22 | 36.4% | 114 | cbioportal |
| Acinar Cell Carcinoma of the Pancreas (JHU, J Pathol 2014) paac_jhu_2014 | Pancreatic Acinar Cell Carcinoma | Ssm | 2 | 23 | 8.7% | 174 | cbioportal |
| Sarcoma (MSK, 2026) lms_msk_2026 | unmapped | Ssm | 3 | 41 | 7.3% | 122 | cbioportal |
| Non-Small Cell Lung Cancer Brain Metastasis (MSK, Nat Commun 2023) bm_nsclc_mskcc_2023 | Lung Non-Small Cell Carcinoma | Ssm | 11 | 322 | 3.4% | 103 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.