MAP3K8

mitogen-activated protein kinase kinase kinase 8

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MAP3K8 Fusion1
(functional)	—UNRESOLVED	Functional	C	Supports Gain Of Function	3	submitted	EID10715 Spitzoid tumors from 49 patients were analyzed by RNA-seq and 33% of cases had either a MAP3K8 fusion or C-terminal deletion. All fusion and truncated transcripts contained MAP3K8 exons 1-8 but were m… (full text at CIViC) PMID 30833747 · Newman et al., 2019 · Open in CIViC	civic

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved4 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Exceptional Responders EXCEPTIONAL_RESPONDERS-ER	unmapped	Ssm

Literature

Data not yet available

No publication linked to this gene yet.