LGR5

leucine rich repeat containing G protein-coupled receptor 5

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
LGR5 delta52
(prognostic)	Oral Cavity Squamous Cell CarcinomaALIAS	Prognostic	B	Supports Poor Outcome	4	submitted

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved8 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Adrenocortical Carcinoma TCGA-ACC	Adrenal Cortical CarcinomaALIAS

Literature

Data not yet available

No publication linked to this gene yet.

LGR5 LGR5FL1
Fluorouracil	Malignant Colorectal NeoplasmCURATED_BROADER	Predictive	D	Supports Resistance	3	submitted	EID9623 Transfected cells with LGR5detla5-8 show significant decreased survival rate in comparison with transfected cells with LGR5FL (p< 0.05). Moreover addition of Anti-LGR5 exon 5 Ab shows significant decr… (full text at CIViC) PMID 27140312 · Osawa et al., 2016 · Open in CIViC	civic