Gene
FOXF1
forkhead box F1
Explore in graph →CI-GENE-00002150HGNC:3809 ENSG00000103241 NCBI 2294 CIViC Approved
Curated evidence
Clinical evidence (1)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 30253191
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FOXF1 Overexpression1 | ||||||||
| Bevacizumab | Malignant Colorectal NeoplasmCURATED_BROADER | Predictive | D | Supports Resistance | 4 | submitted | EID9233As high expression of FOXF1 was associated with higher progression, poorer survival, and increased microvessel density in colorectal cancer (CRC) patients (p < 0.001), the in vitro effects of bevacizu… (full text at CIViC) PMID 30253191 · Wang et al., 2018 · Open in CIViC | civic |
Cohorts
Alteration frequency by cohort (5)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Non-Small Cell Lung Cancer (MSK, 2026) alk_msk_2026 | Lung Non-Small Cell Carcinoma | Ssm | 3 | 46 | 6.5% | 99 |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.