FH — gene · CancerIndex

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FH Deficient2
Bevacizumab + ErlotinibCombination	Hereditary Renal Cell Carcinoma	Predictive	B	Supports Sensitivity Response	3	submitted	EID12939 In the open‑label phase II AVATAR trial (NCT01130519), patients with HLRCC‑associated papillary RCC harboring germline FH pathogenic variants (n = 43) received erlotinib plus bevacizumab, with ORR as … (full text at CIViC) PMID 40532152 · Srinivasan et al., 2025 · Open in CIViC	civic
〃	Papillary Renal Cell Carcinoma	Predictive	B	Supports Sensitivity Response	3	submitted	EID12940 In the open‑label phase II AVATAR trial (NCT01130519), patients with sporadic papillary RCC (n = 40) received erlotinib plus bevacizumab, with ORR as the primary endpoint. They demonstrated a lower OR… (full text at CIViC) PMID 40532152 ·

Cohorts

Alteration frequency by cohort (28)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved28 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Cholangiocarcinoma (National University of Singapore, Nat Genet 2012) chol_nus_2012	Cholangiocarcinoma	Ssm	1	8

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.