Gene
DENND2C
DENN domain containing 2C
Explore in graph →CI-GENE-00043239HGNC:24748 ENSG00000175984 NCBI 163259 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (7)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 34635660
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| RAD51B Associated Mixed Cancers (MSK, NPJ Breast Cancer 2021) mixed_msk_tcga_2021 | unmapped | Ssm | 2 | 4 | 50% | 22 | cbioportal |
| Intrahepatic Cholangiocarcinoma (Mount Sinai 2015) ihch_ismms_2015 | Intrahepatic Cholangiocarcinoma | Ssm | 1 | 8 | 12.5% | 30 | cbioportal |
| Non-Hodgkin Lymphoma (BCGSC, Nature 2011) nhl_bcgsc_2011 | Non-Hodgkin Lymphoma | Ssm | 1 | 14 | 7.1% | 171 | cbioportal |
| Upper Tract Urothelial Carcinoma (Cornell/Baylor/MDACC, Nat Commun 2019) utuc_cornell_baylor_mdacc_2019 | Renal Pelvis and Ureter Urothelial Carcinoma | Ssm | 2 | 37 | 5.4% | 191 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.