CTLA4

cytotoxic T-lymphocyte associated protein 4

Explore in graph →CI-GENE-00042509HGNC:2505 ENSG00000163599 NCBI 1493 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CTLA4 EXPRESSION1
Atezolizumab	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	4	submitted	EID5810 This work shows that across multiple cancer types, responses were observed in patients with tumours expressing high levels of PD-L1, especially when PD-L1 was expressed by tumour-infiltrating immune c… (full text at CIViC) PMID 25428504 · Herbst et al., 2014 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (15)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved15 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Pediatric Pan-cancer (Columbia U, Genome Med 2016) mixed_pipseq_2017	unmapped	Ssm	8	103	7.8%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.