CDK5

cyclin dependent kinase 5

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CDK5 Expression1
(prognostic)	Melanoma	Prognostic	D	Supports Better Outcome	5	submitted	EID8043 These authors demonstrated that cyclin-dependent kinase 5 (CDK5) is instrumental in metastasis of melanomas and that inhibition of this kinase impairs melanoma metastasis. CDK5 phosphorylates the inte… (full text at CIViC) PMID 32193336 · Sharma et al., 2020 · Open in CIViC	civic

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved4 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Refractory Cancers (RC) - Peripheral T-Cell Lymphoma (PTCL) RC-PTCL	Peripheral T-Cell Lymphoma, Not Otherwise Specified

Literature

Data not yet available

No publication linked to this gene yet.