Gene

BCL6

BCL6 transcription repressor

Explore in graph →CI-GENE-00021707HGNC:1001 ENSG00000113916 NCBI 604 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
BCL6 Mutation1
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11915 This study used a combination of RNA-seq, whole genome and targeted sequencing to identify recurrently mutated genes in follicular and diffuse large B-cell lymphoma. They reported 30 genes that had si… (full text at CIViC) PMID 21796119 · Morin et al., 2011 · Open in CIViC	civic
BCL2 Translocation + BCL6 Translocation + MYC TranslocationMYC BCL2 BCL61
(prognostic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Prognostic	C	Supports

Cohorts

Alteration frequency by cohort (85)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved85 cohort rows (showing 35, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Non-Small Cell Cancer (MSK, Cancer Discov 2017) lung_msk_2017	Lung Adenocarcinoma	Ssm	11

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.