Gene
ARHGEF12
Rho guanine nucleotide exchange factor 12
Explore in graph →CI-GENE-00011271HGNC:14193 ENSG00000196914 NCBI 23365 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (12)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Comparison of Cutaneous Sarcomas, CSCC and Deeper Sarcomas (DFCI, 2026) sarcoma_dfci_genie_2026 | unmapped | Ssm | 5 | 48 | 10.4% | 86 | cbioportal |
| Gastric Adenocarcinoma (TMUCIH, PNAS 2015) egc_tmucih_2015 | Gastroesophageal Junction Adenocarcinoma |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.