Gene
APP
amyloid beta precursor protein
Explore in graph →CI-GENE-00011101HGNC:620 ENSG00000142192 NCBI 351 Cancer geneApproved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (2)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
gdcProvenance
- Source
- NCI Genomic Data Commons (open aggregated data)
- Dataset
- GDC top mutated genes by project
- Version
- Data Release 46.0
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- Open-access GDC data (NCI); citation of GDC and originating program requested
- Run
- ING-GDC-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Molecular Profiling to Predict Response to Treatment for Acute Lymphoblastic Leukemia MP2PRT-ALL | unmapped | Ssm | 661 | 1,510 | 43.8% | 85 | gdc |
| Oral Squamous Cell Carcinoma (MD Anderson, Cancer Discov 2013) |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.