Gene
ADAM17
ADAM metallopeptidase domain 17
Explore in graph →CI-GENE-00000417HGNC:195 ENSG00000151694 NCBI 6868 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (7)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 27749842
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Urothelial Carcinoma (Cornell/Trento, Nat Gen 2016) blca_cornell_2016 | Bladder Urothelial Carcinoma | Ssm | 8 | 72 | 11.1% | 138 | cbioportal |
| Breast Cancer (MSK, Clinical Cancer Res 2020) brca_pareja_msk_2020 | Invasive Breast Carcinoma | Ssm | 4 | 60 | 6.7% | 31 | cbioportal |
| Metastatic Renal Clear Cell Carcinoma (Phase 1 Biomarker Trial, Clin Cancer Res. 2016) - iAtlas Harmonized ccrcc_iatlas_choueiri_2016 | Clear Cell Renal Cell Carcinoma | Ssm | 1 | 16 | 6.3% | 171 | cbioportal |
| Medulloblastoma (Sickkids, Nature 2016) mbl_sickkids_2016 | Medulloblastoma | Ssm | 2 | 46 | 4.3% | 76 |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.