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Drugs
One entity per molecule (INN preferred); brand names and development codes are aliases. Approvals are always shown with jurisdiction and indication.
820 drugs
| Drug | Kind | Mechanism | Approvals | Evidence items | Trials | Identifiers |
|---|---|---|---|---|---|---|
| Talquetamab | Monoclonal Antibody | T cell surface glycoprotein CD3 binding agent; G-protein coupled receptor family C group 5 member D binding agent | 4 | 0 | 38 | CHEMBL4594503 |
| Ceritinib | Small Molecule | ALK tyrosine kinase receptor inhibitor; EML4-ALK inhibitor; NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) inhibitor | 3 | 40 | 44 | C115112 · CHEMBL2403108 |
| Pexidartinib | Small Molecule | Macrophage colony stimulating factor receptor inhibitor; Tyrosine-protein kinase receptor FLT3 inhibitor; Stem cell growth factor receptor inhibitor | 3 | 14 | 25 | C88303 · CHEMBL3813873 |
| Asparaginase | Other | Asparagine hydrolytic enzyme | 3 | 10 | 112 | C286 · CHEMBL2108989 |
| Vorinostat | Small Molecule | Histone deacetylase 1 inhibitor; Histone deacetylase 3 inhibitor; Histone deacetylase 6 inhibitor; Histone deacetylase 2 inhibitor | 3 | 8 | 214 | C1796 · CHEMBL98 |
| Metformin | Small Molecule | Mitochondrial complex I (NADH dehydrogenase) inhibitor; Mitochondrial glycerol-3-phosphate dehydrogenase inhibitor | 3 | 5 | 372 | C61612 · CHEMBL1431 |
| Leucovorin | Small Molecule | — | 3 | 4 | 758 | C71631 · CHEMBL1679 |
| Irbesartan | Small Molecule | Type-1 angiotensin II receptor antagonist | 3 | 2 | 0 | C29130 · CHEMBL1513 |
| Ripretinib | Small Molecule | Stem cell growth factor receptor inhibitor; Platelet-derived growth factor receptor alpha inhibitor | 3 | 2 | 13 | C124067 · CHEMBL4216467 |
| Sevabertinib | Small Molecule | — | 3 | 2 | 8 | C185187 · CHEMBL6068074 |
| Verteporfin | Small Molecule | DNA inhibitor | 3 | 2 | 11 | C1014 · CHEMBL5314346 |
| Fedratinib | Small Molecule | Tyrosine-protein kinase receptor FLT3 inhibitor; Tyrosine-protein kinase JAK2 inhibitor | 3 | 1 | 12 | C88293 · CHEMBL1287853 |
| Brexucabtagene Autoleucel | Gene Therapy | B-lymphocyte antigen CD19 binding agent | 3 | 0 | 15 | CHEMBL4594618 |
| Camizestrant | Small Molecule | Estrogen receptor alpha degrader | 3 | 0 | 22 | CHEMBL4650365 |
| Dinutuximab | Monoclonal Antibody | Disialoganglioside GD2 binding agent | 3 | 0 | 20 | CHEMBL3137342 |
| Duvelisib | Small Molecule | PI3-kinase p110-delta subunit inhibitor; PI3-kinase p110-gamma subunit inhibitor | 3 | 0 | 42 | CHEMBL3039502 |
| Loncastuximab Tesirine | Adc | B-lymphocyte antigen CD19 binding agent; DNA cross-linking agent | 3 | 0 | 25 | CHEMBL4297778 |
| Mitotane | Small Molecule | Cytochrome P450 11A1 inhibitor; Cytochrome P450 11B1 inhibitor | 3 | 0 | 9 | CHEMBL1670 |
| Mogamulizumab | Monoclonal Antibody | C-C chemokine receptor type 4 cross-linking agent | 3 | 0 | 33 | CHEMBL1743041 |
| Olaratumab | Monoclonal Antibody | Platelet-derived growth factor receptor alpha antagonist | 3 | 0 | 20 | CHEMBL1743049 |
| Pentostatin | Small Molecule | Adenosine deaminase inhibitor | 3 | 0 | 33 | CHEMBL1580 |
| Pralatrexate | Small Molecule | Dihydrofolate reductase inhibitor | 3 | 0 | 39 | CHEMBL1201746 |
| Tagraxofusp | Other | Interleukin-3 receptor subunit alpha binding agent; Elongation factor 2 inhibitor | 3 | 0 | 20 | CHEMBL4297573 |
| Tebentafusp | Other | Melanocyte protein PMEL binding agent | 3 | 0 | 18 | CHEMBL4297990 |
| Tisotumab Vedotin | Adc | Tubulin inhibitor; Coagulation factor III binding agent | 3 | 0 | 13 | CHEMBL4297841 |
| Valrubicin | Small Molecule | DNA topoisomerase II alpha inhibitor; DNA inhibitor | 3 | 0 | 5 | CHEMBL1096885 |
| Vimseltinib | Small Molecule | — | 3 | 0 | 4 | CHEMBL5095202 |
| Futibatinib | Small Molecule | Fibroblast growth factor receptor inhibitor | 2 | 32 | 21 | C114283 · CHEMBL3701238 |
| Thioguanine | Small Molecule | Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor; DNA inhibitor | 2 | 29 | 84 | C876 · CHEMBL727 |
| Elacestrant | Small Molecule | Estrogen receptor alpha degrader | 2 | 13 | 35 | C120211 · CHEMBL4297509 |
| Revumenib | Small Molecule | Menin/Histone-lysine N-methyltransferase MLL inhibitor; Menin inhibitor | 2 | 11 | 26 | C165776 · CHEMBL4650827 |
| Zongertinib | Small Molecule | — | 2 | 3 | 7 | C199022 · CHEMBL5314498 |
| Nirogacestat | Small Molecule | Gamma-secretase inhibitor | 2 | 2 | 27 | C82383 · CHEMBL1770916 |
| Azathioprine | Small Molecule | Amidophosphoribosyltransferase inhibitor; DNA inhibitor | 2 | 1 | 12 | C290 · CHEMBL1542 |
| Chlorambucil | Small Molecule | DNA inhibitor | 2 | 1 | 47 | C362 · CHEMBL515 |
| Hydroxychloroquine | Small Molecule | Ferriprotoporphyrin IX inhibitor; Toll-like receptor 7 antagonist; Toll-like receptor 9 antagonist | 2 | 1 | 85 | C557 · CHEMBL1535 |
| Margetuximab | Monoclonal Antibody | Receptor protein-tyrosine kinase erbB-2 inhibitor | 2 | 1 | 10 | C91733 · CHEMBL2364649 |
| Tirbanibulin | Small Molecule | Tyrosine-protein kinase SRC inhibitor | 2 | 1 | 9 | C74077 · CHEMBL571546 |
| Tisagenlecleucel | Cell Therapy | B-lymphocyte antigen CD19 binding agent | 2 | 1 | 42 | C102758 · CHEMBL3301574 |
| 5-Aminolevulinic Acid | — | — | 2 | 0 | 29 | — |
| Alitretinoin | Small Molecule | Retinoid receptor agonist | 2 | 0 | 4 | CHEMBL705 |
| Axicabtagene Ciloleucel | Gene Therapy | B-lymphocyte antigen CD19 binding agent | 2 | 0 | 39 | CHEMBL3989989 |
| Calaspargase Pegol | Other | Asparagine hydrolytic enzyme | 2 | 0 | 22 | CHEMBL2108728 |
| Chlormethine | Small Molecule | DNA inhibitor | 2 | 0 | 2 | CHEMBL427 |
| Ciltacabtagene Autoleucel | Gene Therapy | Tumor necrosis factor receptor superfamily member 17 binding agent | 2 | 0 | 8 | CHEMBL4802263 |
| Crisantaspase | Other | Asparagine hydrolytic enzyme | 2 | 0 | 2 | CHEMBL2108931 |
| Estramustine | Small Molecule | — | 2 | 0 | 48 | CHEMBL1575 |
| Histrelin | Other | Gonadotropin-releasing hormone receptor agonist | 2 | 0 | 6 | CHEMBL1201255 |
| Hydroxycarbamide | Small Molecule | Ribonucleoside-diphosphate reductase RR1 inhibitor | 2 | 0 | 2 | CHEMBL467 |
| Idecabtagene Vicleucel | Gene Therapy | Tumor necrosis factor receptor superfamily member 17 binding agent | 2 | 0 | 14 | CHEMBL4298199 |