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Drugs
One entity per molecule (INN preferred); brand names and development codes are aliases. Approvals are always shown with jurisdiction and indication.
820 drugs
| Drug | Kind | Mechanism | Approvals | Evidence items | Trials | Identifiers |
|---|---|---|---|---|---|---|
| Polatuzumab Vedotin | Adc | B-cell antigen receptor complex-associated protein beta chain binding agent; Tubulin inhibitor | 6 | 0 | 70 | CHEMBL3301582 |
| Tafasitamab | Monoclonal Antibody | B-lymphocyte antigen CD19 binding agent | 6 | 0 | 50 | CHEMBL4298047 |
| Treosulfan | Small Molecule | DNA cross-linking agent | 6 | 0 | 28 | CHEMBL455186 |
| Mercaptopurine | Small Molecule | Amidophosphoribosyltransferase inhibitor; DNA inhibitor | 5 | 31 | 173 | C195 · CHEMBL1200751 |
| Lorlatinib | Small Molecule | ALK tyrosine kinase receptor inhibitor; EML4-ALK inhibitor | 5 | 28 | 56 | C113655 · CHEMBL3286830 |
| Capmatinib | Small Molecule | Hepatocyte growth factor receptor inhibitor | 5 | 18 | 51 | C90564 · CHEMBL3188267 |
| Pralsetinib | Small Molecule | Tyrosine-protein kinase receptor RET inhibitor; Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET inhibitor; Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET inhibitor | 5 | 17 | 15 | C132295 · CHEMBL4582651 |
| Inavolisib | Small Molecule | PI3-kinase p110-alpha subunit inhibitor | 5 | 8 | 28 | C132166 · CHEMBL4650215 |
| Adagrasib | Small Molecule | GTPase KRas inhibitor | 5 | 4 | 34 | C157493 · CHEMBL4594350 |
| Lazertinib | Small Molecule | Epidermal growth factor receptor erbB1 inhibitor | 5 | 3 | 31 | C148147 · CHEMBL4558324 |
| Tremelimumab | Monoclonal Antibody | Cytotoxic T-lymphocyte protein 4 inhibitor | 5 | 3 | 194 | C49085 · CHEMBL2108658 |
| Lomustine | Small Molecule | DNA inhibitor | 5 | 2 | 87 | C617 · CHEMBL514 |
| Zolbetuximab | Monoclonal Antibody | Claudin-18 binding agent | 5 | 2 | 21 | C152960 · CHEMBL2109427 |
| Alemtuzumab | Monoclonal Antibody | CAMPATH-1 antigen inhibitor | 5 | 1 | 141 | C1681 · CHEMBL1201587 |
| Datopotamab Deruxtecan | Adc | Tumor-associated calcium signal transducer 2 binding agent; DNA topoisomerase I inhibitor | 5 | 1 | 48 | C151967 · CHEMBL4297939 |
| Aldesleukin | Other | Interleukin-2 receptor agonist | 5 | 0 | 402 | CHEMBL1201438 |
| Belantamab Mafodotin | Adc | Tumor necrosis factor receptor superfamily member 17 binding agent; Tubulin inhibitor | 5 | 0 | 66 | CHEMBL4298209 |
| Cladribine | Small Molecule | DNA inhibitor | 5 | 0 | 78 | CHEMBL1619 |
| Degarelix | Other | Gonadotropin-releasing hormone receptor antagonist | 5 | 0 | 106 | CHEMBL415606 |
| Elranatamab | Monoclonal Antibody | T cell surface glycoprotein CD3 binding agent; Tumor necrosis factor receptor superfamily member 17 binding agent | 5 | 0 | 47 | CHEMBL4297809 |
| Momelotinib | Small Molecule | Tyrosine-protein kinase JAK1 inhibitor; Tyrosine-protein kinase JAK2 inhibitor; Activin receptor type-1 inhibitor | 5 | 0 | 7 | CHEMBL1078178 |
| Romidepsin | Other | Histone deacetylase inhibitor | 5 | 0 | 85 | CHEMBL343448 |
| Tarlatamab | Monoclonal Antibody | T cell surface glycoprotein CD3 binding agent; Delta-like protein 3 binding agent | 5 | 0 | 35 | CHEMBL5095292 |
| Thalidomide | Small Molecule | CRL4(CRBN) E3 ubiquitin ligase inhibitor | 5 | 0 | 236 | CHEMBL468 |
| Vismodegib | Small Molecule | Smoothened homolog inhibitor | 4 | 35 | 75 | C74038 · CHEMBL473417 |
| Infigratinib | Small Molecule | Fibroblast growth factor receptor inhibitor | 4 | 30 | 24 | C88302 · CHEMBL1852688 |
| Tazemetostat | Small Molecule | Histone-lysine N-methyltransferase EZH2 inhibitor | 4 | 24 | 52 | C107506 · CHEMBL3414621 |
| Quizartinib | Small Molecule | Macrophage colony stimulating factor receptor inhibitor; Tyrosine-protein kinase receptor FLT3 inhibitor; Stem cell growth factor receptor inhibitor; Platelet-derived growth factor receptor inhibitor; Tyrosine-protein kinase receptor RET inhibitor | 4 | 22 | 35 | C68936 · CHEMBL576982 |
| Gilteritinib | Small Molecule | Tyrosine-protein kinase receptor FLT3 inhibitor; Tyrosine-protein kinase receptor UFO inhibitor | 4 | 21 | 58 | C116722 · CHEMBL3301622 |
| Tepotinib | Small Molecule | Hepatocyte growth factor receptor inhibitor | 4 | 15 | 22 | C88314 · CHEMBL3402762 |
| Sonidegib | Small Molecule | Smoothened homolog inhibitor | 4 | 7 | 39 | C82385 · CHEMBL2105737 |
| Enasidenib | Small Molecule | Isocitrate dehydrogenase [NADP], mitochondrial inhibitor | 4 | 4 | 34 | C111573 · CHEMBL3989908 |
| Nelarabine | Small Molecule | DNA inhibitor | 4 | 4 | 32 | C1704 · CHEMBL1201112 |
| Vorasidenib | Small Molecule | IDH1/IDH2 inhibitor; Isocitrate dehydrogenase [NADP], mitochondrial inhibitor; Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor | 4 | 4 | 15 | C152914 · CHEMBL4279047 |
| Meloxicam | Small Molecule | Cyclooxygenase-2 inhibitor | 4 | 2 | 4 | C61439 · CHEMBL599 |
| Erlotinib Hydrochloride | Small Molecule | Epidermal growth factor receptor erbB1 inhibitor | 4 | 1 | 184 | C2693 · CHEMBL1079742 |
| Idelalisib | Small Molecule | PI3-kinase p110-delta subunit inhibitor | 4 | 1 | 57 | C78825 · CHEMBL2216870 |
| Pasireotide | Other | Somatostatin receptor 5 agonist; Somatostatin receptor 2 agonist; Somatostatin receptor 1 agonist; Somatostatin receptor 3 agonist | 4 | 1 | 28 | C69131 · CHEMBL3349607 |
| Toripalimab | Monoclonal Antibody | Programmed cell death protein 1 antagonist | 4 | 1 | 335 | C131334 · CHEMBL4297843 |
| Bexarotene | Small Molecule | Retinoid X receptor agonist | 4 | 0 | 27 | CHEMBL1023 |
| Catumaxomab | Monoclonal Antibody | T cell surface glycoprotein CD3 cross-linking agent; Epithelial cell adhesion molecule cross-linking agent | 4 | 0 | 14 | CHEMBL2108581 |
| Clofarabine | Small Molecule | Ribonucleoside-diphosphate reductase RR1 inhibitor; DNA inhibitor; DNA polymerase (alpha/delta/epsilon) inhibitor | 4 | 0 | 132 | CHEMBL1750 |
| Fruquintinib | Small Molecule | Vascular endothelial growth factor receptor inhibitor | 4 | 0 | 89 | CHEMBL4303214 |
| Glasdegib | Small Molecule | Smoothened homolog antagonist | 4 | 0 | 17 | CHEMBL2043437 |
| Glofitamab | Monoclonal Antibody | B-lymphocyte antigen CD20 binding agent; T cell surface glycoprotein CD3 binding agent | 4 | 0 | 75 | CHEMBL4298092 |
| Imiquimod | Small Molecule | Toll-like receptor 7 agonist | 4 | 0 | 114 | CHEMBL1282 |
| Inotuzumab Ozogamicin | Adc | CD22 binding agent; DNA disrupting agent | 4 | 0 | 55 | CHEMBL2108611 |
| Mirvetuximab Soravtansine | Adc | Folate receptor alpha binding agent; Tubulin inhibitor | 4 | 0 | 26 | CHEMBL3545132 |
| Relugolix | Small Molecule | Gonadotropin-releasing hormone receptor antagonist | 4 | 0 | 35 | CHEMBL1800159 |
| Ropeginterferon Alfa-2b | Other | Interferon alpha/beta receptor positive modulator | 4 | 0 | 17 | CHEMBL4297819 |