Skin Squamous Cell Carcinoma — Genomics

Skin Squamous Cell Carcinoma — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

4 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Cutaneous Squamous Cell Carcinoma (DFCI, Clin Cancer Res 2015) cscc_dfarber_2015DFCI

29 cases with simple somatic mutation data · 29 cases total · 2026-01-07 · mapped to Skin Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	23	29	79.3%	cbioportal
2	LRP2	Ssm	16	29	55.2%	cbioportal
3	PKHD1	Ssm	15	29	51.7%	cbioportal
4	SYNE1	Ssm	15	29	51.7%	cbioportal
5	CUBN	Ssm	14	29	48.3%	cbioportal
6	KMT2D	Ssm	14	29	48.3%	cbioportal
7	LRP1B	Ssm	14	29	48.3%	cbioportal
8	MUC2

Data updated 22 days agoSource updated 2026-01-07

Cutaneous Squamous Cell Carcinoma (MD Anderson, Clin Cancer Res 2014) cscc_hgsc_bcm_2014MD Anderson

39 cases with simple somatic mutation data · 39 cases total · 2026-01-07 · mapped to Skin Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53

Cutaneous Squamous Cell Carcinoma (UCSF, NPJ Genom Med 2021) cscc_ucsf_2021UCSF

83 cases with simple somatic mutation data · 83 cases total · 2026-01-07 · mapped to Skin Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN

Cutaneous Squamous Cell Carcinoma (UOW, Front Oncol 2022) cscc_ranson_2022UOW

25 cases with simple somatic mutation data · 25 cases total · 2026-01-16 · mapped to Skin Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
3	TTN

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.