Cancer Family
Skin Neoplasm
CI-CAN-00000051Explore in graph →
Non-malignant346 active trials14 approved drugs74 evidence items
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Cancer Family
CI-CAN-00000051Explore in graph →
Genomics
19 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
29 cases with simple somatic mutation data · 29 cases total · 2026-01-07 · mapped to Skin Squamous Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 23 |
| 29 |
| 79.3% |
| cbioportal |
| 2 | LRP2 | Ssm | 16 | 29 | 55.2% | cbioportal |
| 4 | SYNE1 | Ssm | 15 | 29 | 51.7% | cbioportal |
| 3 | PKHD1 | Ssm | 15 | 29 | 51.7% | cbioportal |
| 5 | CUBN | Ssm | 14 | 29 | 48.3% | cbioportal |
| 9 | NOTCH1 | Ssm | 14 | 29 | 48.3% | cbioportal |
| 7 | LRP1B | Ssm | 14 | 29 | 48.3% | cbioportal |
| 6 | KMT2D | Ssm | 14 | 29 | 48.3% | cbioportal |
| 8 | MUC2 | Ssm | 14 | 29 | 48.3% | cbioportal |
| 10 | CDKN2A | Ssm | 13 | 29 | 44.8% | cbioportal |
| 11 | PRKDC | Ssm | 13 | 29 | 44.8% | cbioportal |
| 12 | KIAA1549 | Ssm | 12 | 29 | 41.4% | cbioportal |
| 13 | ROS1 | Ssm | 12 | 29 | 41.4% | cbioportal |
| 15 | PREX2 | Ssm | 11 | 29 | 37.9% | cbioportal |
| 14 | MAGI2 | Ssm | 11 | 29 | 37.9% | cbioportal |
| 19 | MTUS2 | Ssm | 10 | 29 | 34.5% | cbioportal |
| 17 | BRCA2 | Ssm | 10 | 29 | 34.5% | cbioportal |
| 20 | TET1 | Ssm | 10 | 29 | 34.5% | cbioportal |
| 18 | EP300 | Ssm | 10 | 29 | 34.5% | cbioportal |
| 16 | ATM | Ssm | 10 | 29 | 34.5% | cbioportal |
| 24 | KDR | Ssm | 9 | 29 | 31% | cbioportal |
| 25 | NOTCH2 | Ssm | 9 | 29 | 31% | cbioportal |
| 23 | ERBB4 | Ssm | 9 | 29 | 31% | cbioportal |
| 22 | CREBBP | Ssm | 9 | 29 | 31% | cbioportal |
| 21 | ATR | Ssm | 9 | 29 | 31% | cbioportal |
| 34 | SMARCA4 | Ssm | 8 | 29 | 27.6% | cbioportal |
| 26 | ADGRL2 | Ssm | 8 | 29 | 27.6% | cbioportal |
| 28 | ARID2 | Ssm | 8 | 29 | 27.6% | cbioportal |
| 32 | PTPRD | Ssm | 8 | 29 | 27.6% | cbioportal |
| 30 | LAMA5 | Ssm | 8 | 29 | 27.6% | cbioportal |
Data updated 22 days agoSource updated 2026-01-07