Hematologic Malignancy
Primary Amyloidosis
CI-CAN-00008290Explore in graph →
HematologicNon-malignant32 active trials
- NCIt
- C3819
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Hematologic Malignancy
CI-CAN-00008290Explore in graph →
Clinical trials
106 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT06768489 | A Study of JNJ-79635322 in Combination With Daratumumab With or Without Lenalidomide for Multiple Myeloma, Newly Diagnosed AL Amyloidosis, and High-risk Smoldering Multiple Myeloma or JNJ-79635322 in Combination With Pomalidomide for Multiple Myeloma | recruiting | Phase 1 | 276 | Janssen Research & Development, LLCINDUSTRY | 5 | Sep 25, 2026 | clinicaltrials |
| NCT07172243 | BE.Amycon Biobank & Data Registry UZ Leuven | recruiting | — | 505 | Universitaire Ziekenhuizen KU LeuvenOTHER | 1 |
| Sep 25, 2026 |
| clinicaltrials |
| NCT07215494 | A Clinical Study on Minimal Residual Disease in Patients With Systemic Light Chain Amyloidosis | recruiting | N/A | 50 | Peking University First HospitalOTHER | 1 | Sep 16, 2026 | clinicaltrials |
| NCT07103863 | Multimodal Radiomics Model (18F-FAPI PET/CT + CMR) for AL Cardiac Amyloidosis Prognosis(AL-CA) | enrolling by invitation | — | 49 | Beijing Anzhen HospitalOTHER | 1 | Sep 10, 2026 | clinicaltrials |
| NCT07615270 | A Pilot Study of Anselamimab in Patients With AL Amyloidoma and Measurable Tissue Involvement | not yet recruiting | Early Phase 1 | 5 | Stanford UniversityOTHER | 1 | Aug 21, 2026 | clinicaltrials |
| NCT05145816 | Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosis | recruiting | Phase 1 / Phase 2 | 37 | University of Texas Southwestern Medical CenterOTHER | 1 | Aug 19, 2026 | clinicaltrials |
| NCT06569147 | Elranatamab in Patients With Relapsed or Refractory AL Amyloidosis | recruiting | Phase 1 / Phase 2 | 49 | Dana-Farber Cancer InstituteOTHER | 1 | Aug 19, 2026 | clinicaltrials |
| NCT07751471 | BCMA/GPRC5D Trispecific Antibody Treatment for Newly Diagnosed Amyloidosis (AL-004)(AL-004) | not yet recruiting | Phase 2 | 20 | Institute of Hematology & Blood Diseases Hospital, ChinaOTHER | 1 | Aug 7, 2026 | clinicaltrials |
| NCT07638683 | A Phase II Study to Evaluate the Efficacy and Safety of Teclistamab in Combination With Daratumumab (Tec-Dara) in Newly Diagnosed Multiple Myeloma With Concurrent Light Chain Amyloidosis (MM+AL). | recruiting | Phase 2 | 30 | Shanghai Zhongshan HospitalOTHER | 1 | Aug 3, 2026 | clinicaltrials |
| NCT04847453 | Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis | active not recruiting | Phase 1 | 24 | National Cancer Institute (NCI)NIH | 1 | Jul 31, 2026 | clinicaltrials |
| NCT07335887 | Sonrotoclax Plus Dexamethasone With or Without Daratumumab Regimen in Patients With t(11;14) Primary AL Amyloidosis | recruiting | Phase 2 | 39 | Peking University People's HospitalOTHER | 1 | Jul 28, 2026 | clinicaltrials |
| NCT06649695 | A Phase II Trial of Teclistamab in Participants With Previously Treated Immunoglobulin Light-chain (AL) Amyloidosis | active not recruiting | Phase 2 | 30 | European Myeloma Network B.V.NETWORK | 6 | Jul 20, 2026 | clinicaltrials |
| NCT06855121 | The Norwegian Immunotherapy in Multiple Myeloma Study(NIMMS) | recruiting | — | 400 | St. Olavs HospitalOTHER | 1 | Jul 20, 2026 | clinicaltrials |
| NCT04754945 | Isatuximab as Upfront Therapy for the Treatment of High Risk AL Amyloidosis | active not recruiting | Phase 1 | 11 | Emory UniversityOTHER | 1 | Jul 14, 2026 | clinicaltrials |
| NCT06097832 | Study of NXC-201 CAR-T in Patients With Light Chain (AL) Amyloidosis(NEXICART-2) | active not recruiting | Phase 1 / Phase 2 | 45 | Nexcella Inc.INDUSTRY | 1 | Jul 14, 2026 | clinicaltrials |
| NCT05451771 | Venetoclax-Dexamethasone in Relapsed and/or Refractory t(11;14) Amyloidosis | active not recruiting | Phase 1 / Phase 2 | 53 | Columbia UniversityOTHER | 1 | Jul 10, 2026 | clinicaltrials |
| NCT07689331 | Hungarian National Systemic Amyloidosis Registry(AMYREG) | recruiting | — | 300 | Semmelweis UniversityOTHER | 1 | Jul 8, 2026 | clinicaltrials |
| NCT06192979 | Optimize First-line Treatment for AL Amyloidosis With t (11; 14) | recruiting | N/A | 41 | Jin Lu, MDOTHER | 1 | Jul 7, 2026 | clinicaltrials |
| NCT04504825 | A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES) | active not recruiting | Phase 3 | 125 | Alexion Pharmaceuticals, Inc.INDUSTRY | 19 | Jul 2, 2026 | clinicaltrials |
| NCT07081646 | A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.(ALACRITY) | recruiting | Phase 1 / Phase 2 | 91 | Alexion Pharmaceuticals, Inc.INDUSTRY | 3 | Jul 2, 2026 | clinicaltrials |
| NCT06971848 | Evaluation of Skin Tests in Biotherapy Allergies(ETCABIO) | recruiting | N/A | 70 | University Hospital, AngersOTHER_GOV | 1 | Jun 18, 2026 | clinicaltrials |
| NCT04512235 | A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES) | active not recruiting | Phase 3 | 281 | Alexion Pharmaceuticals, Inc.INDUSTRY | 19 | Jun 17, 2026 | clinicaltrials |
| NCT07626476 | Autologous BCMA-targeted CAR-T Cell Injection for Relapsed/Refractory Light Chain Amyloidosis | recruiting | Early Phase 1 | 30 | Beijing Boren HospitalOTHER | 1 | Jun 4, 2026 | clinicaltrials |
| NCT07624760 | Early Detection of Amyloidosis in Monoclonal Gammopathy Using Nuclear Medicine Imaging(MGUS-PET) | not yet recruiting | N/A | 50 | University of ZurichOTHER | 1 | Jun 3, 2026 | clinicaltrials |
| NCT06022939 | Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis | recruiting | Phase 3 | 338 | SWOG Cancer Research NetworkNETWORK | 1 | May 6, 2026 | clinicaltrials |
| NCT07448935 | One Gene, Two Diseases: the Pathologic Role of IGLV1-44 in AL Amyloidosis and POEMS(ALPS) | recruiting | — | 100 | Fondazione IRCCS Policlinico San Matteo di PaviaOTHER | 1 | May 6, 2026 | clinicaltrials |
| NCT04839003 | A Registry of AL Amyloidosis (ReAL)(ReAL) | recruiting | — | 5,000 | Fondazione IRCCS Policlinico San Matteo di PaviaOTHER | 1 | Apr 16, 2026 | clinicaltrials |
| NCT06205953 | A EUropean REgistry and Sample Sharing networK to Promote the Diagnosis and Management of Light Chain Amyloidosis (EUREKA)(EUREKA) | recruiting | — | 400 | Fondazione IRCCS Policlinico San Matteo di PaviaOTHER | 6 | Apr 16, 2026 | clinicaltrials |
| NCT06383143 | Promoting Diagnosis and Management of AL in Italy (ProDigALIty)(ProDigALIty) | recruiting | — | 760 | Fondazione IRCCS Policlinico San Matteo di PaviaOTHER | 1 | Apr 16, 2026 | clinicaltrials |
| NCT05898646 | Daratumumab Maintenance Therapy for Improving Survival in Patients With Light Chain Amyloidosis, EMILIA Trial | recruiting | Phase 2 | 96 | Mayo ClinicOTHER | 1 | Mar 30, 2026 | clinicaltrials |
| NCT01408225 | Ohio State University Multiple Myeloma and Amyloidosis Data Registry and Sample Resource(B-SCR-MM) | recruiting | — | 5,000 | Ohio State University Comprehensive Cancer CenterOTHER | 1 | Mar 23, 2026 | clinicaltrials |
| NCT07448779 | Investigating the Pathogenic Role of N-glycosylation in AL Amyloidosis: Molecular Bases, Diagnosis, and Treatment(GlycAL) | recruiting | — | 100 | Fondazione IRCCS Policlinico San Matteo di PaviaOTHER | 1 | Mar 4, 2026 | clinicaltrials |
| NCT04270175 | Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab | active not recruiting | Phase 2 | 15 | Weill Medical College of Cornell UniversityOTHER | 1 | Feb 27, 2026 | clinicaltrials |
| NCT01199562 | Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant | active not recruiting | — | 153 | City of Hope Medical CenterOTHER | 1 | Jan 28, 2026 | clinicaltrials |
| NCT03618537 | Ixazomib Maintenance Study in Patients With AL Amyloidosis | active not recruiting | Phase 2 | 17 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Dec 4, 2025 | clinicaltrials |
| NCT02641145 | Molecular Imaging of Primary Amyloid Cardiomyopathy(MICA) | recruiting | N/A | 171 | Brigham and Women's HospitalOTHER | 1 | Nov 14, 2025 | clinicaltrials |
| NCT03315026 | Siltuximab to Decrease Symptom Burden After Autologous Stem Cell Transplantation for Patients With Multiple Myeloma and AL Amyloidosis | active not recruiting | Phase 2 | 30 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Nov 4, 2025 | clinicaltrials |
| NCT07085559 | Safety and Efficacy of Metabolically Armed BCMA CAR-T Cells (Meta10-BCMA) in the Treatment of r/r Plasma Cell Neoplasms Clinical Research | recruiting | Early Phase 1 | 36 | Anhui Provincial HospitalOTHER_GOV | 1 | Jul 25, 2025 | clinicaltrials |
| NCT07079423 | Teclistamab in Newly Diagnosed Mayo Stage IIIB AL Amyloidosis | recruiting | Phase 2 | 35 | Peking Union Medical College HospitalOTHER | 1 | Jul 23, 2025 | clinicaltrials |
| NCT07055724 | Study of Eque-cel CAR-T Therapy in Newly Diagnosed Severe AL Amyloidosis | not yet recruiting | Phase 2 | 17 | Nanjing IASO Biotechnology Co., Ltd.INDUSTRY | 0 | Jul 9, 2025 | clinicaltrials |
| NCT06935162 | Teclistamab in Previously Treated AL Amyloidosis | recruiting | Phase 2 | 30 | Peking Union Medical College HospitalOTHER | 1 | May 25, 2025 | clinicaltrials |
| NCT06699394 | Prospective Study of Teclistamab in the Treatment of Systemic AL Amyloidosis | recruiting | N/A | 20 | Peking University People's HospitalOTHER | 1 | Apr 24, 2025 | clinicaltrials |
| NCT06376214 | Daratumumab for Patients With Light Chain Amyloidosis | recruiting | N/A | 100 | Nanjing University School of MedicineOTHER | 1 | Apr 19, 2024 | clinicaltrials |
| NCT04210791 | Autologous Stem Cell Transplantation for Patients With AL Amyloidosis | enrolling by invitation | — | 500 | Nanjing University School of MedicineOTHER | 1 | Feb 26, 2024 | clinicaltrials |
| NCT06065852 | National Registry of Rare Kidney Diseases(RaDaR) | recruiting | — | 35,000 | UK Kidney AssociationOTHER | 1 | Oct 4, 2023 | clinicaltrials |
Data updated 4 days agoSource updated Sep 25, 2026source: clinicaltrials