Peritoneal Mesothelial Neoplasm — Variants & evidence

Peritoneal Mesothelial Neoplasm — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

2 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
EGFR Mutation1
Cytoreductive Surgery + Hyperthermic Intraperitoneal ChemotherapyCombination	Predictive	B	Supports Sensitivity Response	4	accepted	EID5923 25 patients with metastatic peritoneal mesothelioma were treated with surgical cytoreduction consolidated with intraperitoneal hyperthermic chemotherapy (CRS/IPHC). 8 of the patients carried EGFR muta… (full text at CIViC) PMID 20942962 · Foster et al., 2010 · Open in CIViC	civic
NF2 Y177fs1
Carboplatin + CisplatinSubstitutes	Predictive	C	Supports Resistance	3	accepted	EID649 A frameshift mutation in NF2 at position Y177 was found in a patient who responded poorly to therapy and died within 8 months of diagnosis. Initially treated with 3 cycles of systemic chemotherapy wit… (full text at CIViC) PMID 25798586 · Sheffield et al., 2015 · Open in CIViC	civic

Data updated 8 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.