Ovarian Gynandroblastoma — Variants & evidence

Ovarian Gynandroblastoma — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

4 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
DICER1 E1705K1
(diagnostic)	Diagnostic	C	Supports Positive	2	accepted	EID11480 In an analysis of a range of different ovarian sex cord-stromal tumors, 2 of 5 gynandroblastomas were found to have the DICER1 E1705K hotspot mutation supporting a role for DICER1 in a subset of these… (full text at CIViC) PMID 26428316 · Conlon et al., 2015 · Open in CIViC	civic
DICER1 Loss-of-function1
(predisposing)	Predisposing	A	Supports Predisposition	2	submitted	EID11479 In an analysis of 107 patients enrolled in the International Ovarian and Testicular Stromal Tumor Registry, 5 had gynandroblastoma (14-32 yo). 4 of the 4 gynandroblastoms with material available for … (full text at CIViC) PMID 29037807 · Schultz et al., 2017 · Open in CIViC	civic
DICER1 RNase IIIb Mutation1
(diagnostic)	Diagnostic	C	Supports Positive	2	submitted	EID11481 Genomic analysis identified DICER1 RNase IIIb domain hotspot mutations in 3 of 16 cases of gynandroblastoma, leading the authors to suggest that DICER1 hotspot mutations are a key driver in a subset o… (full text at CIViC) PMID 29660837 · Wang et al., 2018 · Open in CIViC	civic
DICER1 Loss-of-function + DICER1 RNase IIIb Mutation1
(diagnostic)	Diagnostic	B	Supports Positive	3	submitted	EID11478 In an analysis of 107 patients enrolled in the International Ovarian and Testicular Stromal Tumor Registry, 5 had gynandroblastoma (14-32 yo). 4 of the 4 gynandroblastoms with material available for … (full text at CIViC) PMID 29037807 · Schultz et al., 2017 · Open in CIViC	civic

Data updated 17 minutes agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.