Osteoclastic Giant Cell-Rich Tumor of Bone — Variants & evidence

Osteoclastic Giant Cell-Rich Tumor of Bone — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

3 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items (3 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
H3-3A G35W3
(diagnostic)	Giant Cell Tumor of BoneALIAS	Diagnostic	B	Supports Positive	4	accepted	EID6469 In this study, the authors analyzed 53 cases of giant cell tumour of bone using capillary sequencing and massively parallel sequencing. They identified histone 3.3 mutations in 49/53 cases (92%). All … (full text at CIViC) PMID 24162739 · Behjati et al., 2013 · Open in CIViC	civic
〃	Giant Cell Tumor of BoneALIAS	Diagnostic	B	Supports Positive	4	accepted	EID12749 In this 2015 study, formalin-fixed paraffin-embedded (FFPE) tissue samples were retrieved from the diagnostic pathology archives of the Royal National Orthopaedic Hospital (RNOH) and the Basel Bone Tu… (full text at CIViC) PMID 27499898 · Presneau et al., 2015 · Open in CIViC	civic
〃	Giant Cell Tumor of BoneALIAS	Diagnostic	B	Supports Positive	3	accepted	EID12750 In this 2015 study, formalin-fixed, paraffin-embedded (FFPE) tumor samples diagnosed between 1996 and 2014 as giant cell tumor of bone (GCTB), chondroblastoma, chondromyxoid fibroma, aneurysmal bone c… (full text at CIViC) PMID 26457357 · Cleven et al., 2015 · Open in CIViC	civic

Data updated 22 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.