Subtype
Non-Clear Cell Renal Cell Carcinoma
CI-CAN-00008117Explore in graph →
- NCIt
- C202497
Loading cancer entity…
Subtype
CI-CAN-00008117Explore in graph →
Variants & evidence
6 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FGFR2 Overexpression1 | ||||||||
| (prognostic) | Papillary Renal Cell Carcinoma | Prognostic | B | Supports Poor Outcome | 4 | submitted | EID6454Only 12/118(10.2%) of patients with type I papillary renal cell carcinoma expressed FGFR2 whereas 37/96 (38.5%) patients with type II papillary renal cell carcinoma(P=0.001). In addition, FGFR2 expre… (full text at CIViC) PMID 27379982 · Tsimafeyeu et al., 2017 · Open in CIViC | civic |
| FH Deficient1 | ||||||||
| Bevacizumab + ErlotinibCombination | Papillary Renal Cell Carcinoma | Predictive | B | Supports Sensitivity Response | 3 | submitted | EID12940In the open‑label phase II AVATAR trial (NCT01130519), patients with sporadic papillary RCC (n = 40) received erlotinib plus bevacizumab, with ORR as the primary endpoint. They demonstrated a lower OR… (full text at CIViC) PMID 40532152 · Srinivasan et al., 2025 · Open in CIViC | civic |
| FLCN Mutation1 | ||||||||
| Everolimus | Papillary Renal Cell Carcinoma | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID5990In a patient with Birt-Hogg-Dubé syndrome-associated papillary renal cell carcinoma use of everolimus as sixth-line systematic treatment exhibited a relatively long-term effect as compared with the pr… (full text at CIViC) PMID 23995526 · Nakamura et al., 2013 · Open in CIViC | civic |
| MET Mutation1 | ||||||||
| Foretinib | Papillary Renal Cell Carcinoma | Predictive | B | Supports Sensitivity Response | 3 | accepted | EID796In a retrospective analysis of 74 patients with papillary renal cell carcinoma, treated with foretinib, MET germline mutation was associated with improved response rate. A response was observed in 5 … (full text at CIViC) PMID 23213094 · Choueiri et al., 2013 · Open in CIViC | civic |
| VHL M1FS (c.1_17del17)1 | ||||||||
| (oncogenic) | Chromophobe Renal Cell Carcinoma | Oncogenic | C | Supports Oncogenicity | 1 | accepted | EID1945This somatic mutation was detected in two samples from a single patient with chromophobe renal cell carcinoma (a 74 year old male). The tumor also harbored a silent T157= (c.471T>A) somatic variant. PMID 15932632 · van Houwelingen et al., 2005 · Open in CIViC | civic |
| ZHX2 Overexpression1 | ||||||||
| Sorafenib | Papillary Renal Cell Carcinoma | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID9114Efficacy of second-line sorafenib treatment (initially 12.5 mg/day, escalated to 25 mg/day) in a 82-year old male patient with type 2 papillary renal cell carcinoma was confirmed with a partial respon… (full text at CIViC) PMID 32743370 · Morinaga et al., 2019 · Open in CIViC | civic |
Data updated 19 minutes agoSource updated unknownsource: civic (CC0)
Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.