Neoplasm by Cause — Variants & evidence

Neoplasm by Cause — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

4 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items (4 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NOTCH1 L1678P1
Nirogacestat	Adult T-Cell Leukemia/Lymphoma	Predictive	C	Supports Sensitivity Response	3	submitted	EID5921 Genetic evaluation of a single patient with a complete response in a phase 1 trial of PF-03084014 revealed the presence of a known activating NOTCH1 mutation, L1678P. PMID 26407235 · Papayannidis et al., 2015 · Open in CIViC	civic
PLCG1 S345F1
(oncogenic)	Adult T-Cell Leukemia/Lymphoma	Oncogenic	D	Supports Oncogenicity	3	submitted	EID11795 The PLCG1 S345F mutation has been reported as a hotspot mutation in adult T-cell Leukemia/Lymphoma (ATL). This study performed in vitro characterization of the mutation by identifying an ATL cell line… (full text at CIViC) PMID 36442790 · Prawiro et al., 2023 · Open in CIViC	civic
PRKCB D427N1
(diagnostic)	Adult T-Cell Leukemia/Lymphoma	Diagnostic	D	Supports Positive	3	accepted	EID6654 PRKCB was mutated in 33% of ATLL cases. 93% of these mutations were within the catalytic domain at Asp427. This gene has not been reported to be significantly mutated in any other cancers. Indeed thi… (full text at CIViC) PMID 26437031 · Kataoka et al., 2015 · Open in CIViC	civic
PRKCB Mutation1
(prognostic)	Adult T-Cell Leukemia/Lymphoma	Prognostic	D	Supports Poor Outcome	3	submitted	EID11794 For aggressive adult T cell leukemia/lymphoma (ATL), PRKCB mutations were associated with an adverse outcome (Hard Ratio: 2.07; 95% CI: 1.29-3.31; P-value: 0.003). In this study, 414 ATL patients were… (full text at CIViC) PMID 29084771 · Kataoka et al., 2018 · Open in CIViC	civic

Data updated 2 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.