Meningeal Neoplasm — Variants & evidence

Meningeal Neoplasm — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

5 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items (5 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
BAP1 c.122+1G>T1
(predisposing)	Meningioma	Predisposing	C	Supports Predisposition	2	submitted	EID13245 Jadun et al. reported an adolescent girl with a skull-base meningothelial meningioma, WHO grade 1. Initial germline testing of NF2, LZTR1, and SMARCB1 was negative. Subsequent paired tumor-normal geno… (full text at CIViC) PMID 41442315 · Jadun et al., 2026 · Open in CIViC	civic
LEPR UNDEREXPRESSION1
(prognostic)	Meningioma	Prognostic	B	Supports Poor Outcome	2	accepted	EID1054 144 cases (discovery set: N=62 discovery; Independent validation set: N = 82) of meningiomas were analyzed for transcriptional features defining aggressive clinical course (recurrent, malignantly prog… (full text at CIViC) PMID 26894859 · Schmidt et al., 2016 · Open in CIViC	civic
PTTG1 OVEREXPRESSION1
(prognostic)	Meningioma	Prognostic	B	Supports Poor Outcome	2	accepted	EID1053 144 cases (discovery set: N=62 discovery; independent validation set: N = 82) of meningiomas were analyzed for transcriptional features defining aggressive clinical course (recurrent, malignantly prog… (full text at CIViC) PMID 26894859 · Schmidt et al., 2016 · Open in CIViC	civic
SMO W535L2
(diagnostic)	Olfactory Groove Meningioma	Diagnostic	C	Supports N/A	2	submitted	EID1928 Boetto et al used Sanger sequencing to query SMO mutations (W535L and L412F) in 79 confirmed olfactory groove meningiomas and identified 1 patient with W535L (and 21 with L412F). PMID 28082415 · Boetto et al., 2017 · Open in CIViC	civic
〃	Meningioma	Diagnostic	D	Supports N/A	3	submitted	EID1927 Brastianos et al identified SMO W535L in 2 tumors from a set of 65 meningiomas, notably in meningiomas lacking NF2 alterations and of the meningiothelial subtype. The variants displayed high somatic v… (full text at CIViC) PMID 23334667 · Brastianos et al., 2013 · Open in CIViC	civic

Data updated 16 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.