Melanocytic Neoplasm

A375 melanoma cells containing an inducible shRNA for STAG3 were grown as xenograft tumors in nude mice. The mice in which STAG3 was silenced had tumors that were less sensitive to vemurafenib-induced… (full text at CIViC)

PMID 27500726 · Shen et al., 2016 · Open in CIViC

A cohort of 28 patients with malignant melanoma, with previously excised high-risk lesions were evaluated for STAT1 and STAT2 expression prior to treatment with v. interferon-alpha 2b (IFN-a2b). Stain… (full text at CIViC)

PMID 15668815 · Lesinski et al., 2005 · Open in CIViC

The examination of interferon-resistant melanoma cell lines in relation to STAT5 expression, indicated a correlation between overexpression and resistance to interferon α (IFNα) immunotherapy. From an… (full text at CIViC)

PMID 16169484 · Wellbrock et al., 2005 · Open in CIViC

Preclinical study in melanoma cell lines. TBK1 depletion (siRNA) inhibited migration and invasion, whereas its constitutive overexpression led to an increase in invasion. In MEK-resistant NRAS mutant … (full text at CIViC)

PMID 24962318 · Vu et al., 2014 · Open in CIViC

To understand the role of TCF19 expression in NRAS-mutant melanoma, an analysis of a TCGA cutaneous melanoma data set showed that patient survival was inversely correlated with levels of BRD4 and TCF1… (full text at CIViC)

PMID 29650805 · Echevarría-Vargas et al., 2018 · Open in CIViC

In patients with acral lentiginous melanoma, those with amplification of TERT had shorter overall survival.

PMID 25219713 · Diaz et al., 2014 · Open in CIViC

In patients with nonacral cutaneous melanoma, those with mutations in the TERT promoter had shorter overall survival than wild-type patients.

PMID 25217772 · Griewank et al., 2014 · Open in CIViC

An in vitro study of M229 (a human melanoma cell line) endogenously expressing wildtype PTEN and BRAF V600E (a known BRAF inhibitor sensitizing mutation) found that PTEN knockdown cells (achieved via … (full text at CIViC)

PMID 24265155 · Shi et al., 2014 · Open in CIViC

Tumors from a cohort of melanoma patients were analyzed with whole exome sequencing. Median nonsynonymous exonic mutational load was 197 mutations per sample (range: 7 to 5854). The cohort was stratif… (full text at CIViC)

PMID 26359337 · Van Allen et al., 2015 · Open in CIViC

TPT1(TCTP) overexpression was detected in several tumour types and silencing of TPT1 was shown to induce tumour reversion. There is a reciprocal repression between TPT1 and P53. Sertraline interacts w… (full text at CIViC)

PMID 28751755 · Boia-Ferreira et al., 2017 · Open in CIViC

A TRIM24-BRAF fusion was identified in a single patient with metastatic melanoma that was "pan-negative" for driver mutations. A cell-line (293H) ectopically expressing the TRIM24-BRAF fusion was foun… (full text at CIViC)

PMID 24345920 · Hutchinson et al., 2013 · Open in CIViC

Foundation One NGS assay and targeted RNAseq identified PAPSS1-BRAF fusion in a melanoma sample. Further BRAF fusions (TRIM24-BRAF) were identified in TCGA and additional samples. Ectopic expression o… (full text at CIViC)

PMID 24345920 · Hutchinson et al., 2013 · Open in CIViC

In this study we report that nonspitzoid metastasizing melanomas of adults may also harbor NTRK fusions and that NTRK expression can be immunohistochemically detected in these tumors. Of 751 melanomas… (full text at CIViC)

PMID 29683819 · Lezcano et al., 2018 · Open in CIViC

Analysis of BRAF fusions in 20,573 tumors, across 12 distinct tumor types. BRAF fusions were identified in 55 (0.3%) patients and enriched in spitzoid melanoma, pilocytic astrocytomas, pancreatic acin… (full text at CIViC)

PMID 26314551 · Ross et al., 2016 · Open in CIViC