TPT1 Overexpression

CI-VAR-00003179Explore in graph →CIViC 2239

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Melanoma1
TPT1 Overexpression	Sertraline	Predictive	D	Supports Sensitivity Response	2	submitted	EID5999 TPT1(TCTP) overexpression was detected in several tumour types and silencing of TPT1 was shown to induce tumour reversion. There is a reciprocal repression between TPT1 and P53. Sertraline interacts w… (full text at CIViC) PMID 28751755 · Boia-Ferreira et al., 2017 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.