Cancer
Malignant Rectal Neoplasm
CI-CAN-00008012Explore in graph →
Top-level388 active trials1 approved drugs5 evidence items
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Cancer
CI-CAN-00008012Explore in graph →
Clinical trials
1,551 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (153)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT07020247 | Personalized Long-course Radiotherapy Plus Chemotherapy With or Without Immunotherapy for LARC: PALACE Study | recruiting | Phase 3 | 184 | West China HospitalOTHER | 1 | Jun 13, 2025 | clinicaltrials |
| NCT01804790 | Efficacy of Neoadjuvant Folfirinox Regimen in Patients With Resectable Locally Advanced Rectal Cancer(Néofirinox) | completed | Phase 3 | 461 | UNICANCEROTHER | 1 | Jun 12, 2025 | clinicaltrials |
| NCT06968221 | Bovine Reinforcement in Stomach, Colorectal and Lung Operation | recruiting | Phase 3 | 172 | Shanghai Cingularbio Co. LtdINDUSTRY | 1 | May 15, 2025 | clinicaltrials |
| NCT05646511 | TNT of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer(ENSEMBLE) | recruiting | Phase 3 | 608 | National Cancer Center Hospital EastOTHER | 1 | Apr 3, 2025 | clinicaltrials |
| NCT04316013 | Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: the VAPOR-C Trial | terminated | Phase 3 | 254 | Peter MacCallum Cancer Centre, AustraliaOTHER | 3 | Mar 14, 2025 | clinicaltrials |
| NCT02843191 | Consolidation Chemotherapy for Locally Advanced Mid or Low Rectal Cancer After Neoadjuvant Concurrent Chemoradiotherapy | active not recruiting | Phase 3 | 358 | Kyung Hee University Hospital at GangdongOTHER | 1 | Dec 27, 2024 | clinicaltrials |
| NCT00297791 | COLOR II: Laparoscopic Versus Open Rectal Cancer Removal(COLORII) | completed | Phase 3 | 1,044 | Nova Scotia Health AuthorityOTHER | 9 | Aug 21, 2024 | clinicaltrials |
| NCT05939687 | Prophylactic Mesh Placement During Stoma Closure After Low Anterior Resection(ProMeLAR) | recruiting | Phase 3 | 142 | Blokhin's Russian Cancer Research CenterOTHER | 1 | Aug 7, 2024 | clinicaltrials |
| NCT06450574 | Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Ttransanal Endoscopic Microsurgery in T1 N0, M0 Rectal Cancer (TAUTEM-T1 Study)(TAUTEM-T1) | not yet recruiting | Phase 3 | 106 | Corporacion Parc TauliOTHER | 0 | Jun 10, 2024 | clinicaltrials |
| NCT06443671 | Neoadjuvant Fruquintinib Plus Tislelizumab Combined With mCapeOX Versus CapeOX for Mid-high pMMR/MSS Locally Advanced Rectal Cancer(PKUCH-R09) | not yet recruiting | Phase 2 / Phase 3 | 132 | Peking University Cancer Hospital & InstituteOTHER | 1 | Jun 5, 2024 | clinicaltrials |
| NCT01345175 | Rifaximin and Placebo in the Treatment of Bowel Dysfunction After Anterior Resection for Rectal Cancer | completed | Phase 3 | 69 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | May 14, 2024 | clinicaltrials |
| NCT06229041 | Total Neoadjuvant Treatment ±Immunotherapy for High Risk Locally Advanced Rectal Cancer (TNTi) | recruiting | Phase 3 | 472 | Peking University Cancer Hospital & InstituteOTHER | 1 | Jan 29, 2024 | clinicaltrials |
| NCT06097416 | Neoadjuvant Chemoradiotherapy Versus Total Neoadjuvant Therapy in the Treatment of T3 Rectal Cancer | not yet recruiting | Phase 3 | 100 | St. James's Hospital, IrelandOTHER | 0 | Oct 25, 2023 | clinicaltrials |
| NCT02551237 | Neoadjuvant Treatment for Advanced Rectal Carcinoma(NACRE) | completed | Phase 3 | 103 | UNICANCEROTHER | 1 | Oct 13, 2023 | clinicaltrials |
| NCT01606098 | The Role of Surgery of the Primary Tumour in Patients With Synchronous Unresectable Metastases of Colorectal Cancer(CAIRO4) | completed | Phase 3 | 206 | Dutch Colorectal Cancer GroupOTHER | 2 | Sep 13, 2023 | clinicaltrials |
| NCT02031939 | Randomized Controlled Study on Optimize Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer | unknown | Phase 3 | 556 | Sun Yat-sen UniversityOTHER | 1 | Aug 25, 2023 | clinicaltrials |
| NCT05984485 | The Efficacy of Primary Total Mesorectal Excision (TME) Surgery Versus Neoadjuvant Chemotherapy Combined With TME Surgery in Low-risk Locally Advanced Rectal Cancer(TaLaR-02) | recruiting | Phase 3 | 766 | Sun Yat-sen UniversityOTHER | 1 | Aug 9, 2023 | clinicaltrials |
| NCT00303628 | Postoperative Chemotherapy With or Without Bevacizumab for Patients With Stage II or III Rectal Cancer | terminated | Phase 3 | 355 | ECOG-ACRIN Cancer Research GroupNETWORK | 4 | Jul 6, 2023 | clinicaltrials |
| NCT00979680 | Sphincter-preserving Surgery After Preoperative Treatment of Ultra-low Rectal Carcinoma(GRECCAR1) | completed | Phase 3 | 207 | Institut du Cancer de Montpellier - Val d'AurelleOTHER | 1 | Jun 29, 2023 | clinicaltrials |
| NCT04087421 | Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome | recruiting | Phase 3 | 114 | University of AarhusOTHER | 1 | May 3, 2023 | clinicaltrials |
| NCT04389086 | Induction Chemotherapy for Locally Recurrent Rectal Cancer(PelvEx II) | recruiting | Phase 3 | 364 | Catharina Ziekenhuis EindhovenOTHER | 5 | Sep 6, 2022 | clinicaltrials |
| NCT01648894 | Influence of Lengthening the Interval Between Radiochemotherapy and Surgery on Complete Pathological Response in Rectal Cancer(GRECCAR6) | completed | Phase 3 | 265 | Assistance Publique - Hôpitaux de ParisOTHER | 1 | Jul 25, 2022 | clinicaltrials |
| NCT03957733 | Phase II/III Study to Assess the Efficacy of Neoadjuvant Consolidation Chemotherapy in Rectal Cancer Patients. | unknown | Phase 2 / Phase 3 | 338 | King Abdullah Medical CityOTHER_GOV | 1 | Apr 6, 2022 | clinicaltrials |
| NCT05201430 | Neoadjuvant FOLFOXIRI Versus CapeOX Chemotherapy for Local Advanced Rectal Cancer(RCNAC) | recruiting | Phase 3 | 300 | Fudan UniversityOTHER | 1 | Mar 4, 2022 | clinicaltrials |
| NCT04167436 | Fit for Surgery. Multimodal Prehabilitation in Colorectal Cancer Patients | unknown | Phase 2 / Phase 3 | 48 | Zealand University HospitalOTHER | 1 | Mar 3, 2022 | clinicaltrials |
| NCT01308190 | Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Total Mesorectal Excision in T2-T3s N0, M0 Rectal Cancer | completed | Phase 3 | 173 | Corporacion Parc TauliOTHER | 1 | Nov 23, 2021 | clinicaltrials |
| NCT05079438 | Dendrobium Huoshanense Suppository in Rectal Cancer | unknown | Phase 3 | 168 | Zhejiang Cancer HospitalOTHER | 1 | Oct 15, 2021 | clinicaltrials |
| NCT01927497 | Biological Mesh Closure of the Pelvic Floor After Extralevator Abdomino Perineal Resection for Rectal Cancer(BIOPEX) | completed | Phase 3 | 104 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)OTHER | 1 | Aug 17, 2021 | clinicaltrials |
| NCT02533271 | Optimization of Preoperative Treatment in Locally Advanced Rectal Cancer(STELLAR) | unknown | Phase 3 | 600 | Chinese Academy of Medical SciencesOTHER | 1 | Jul 16, 2021 | clinicaltrials |
| NCT04103697 | Neoadjuvant Chemotherapy in Patients With Intermediate Risk Upper and Mid Rectal Cancer(RuCorT-01) | unknown | Phase 3 | 560 | Blokhin's Russian Cancer Research CenterOTHER | 1 | Feb 9, 2021 | clinicaltrials |
| NCT04134897 | Neoadjuvant Chemotherapy in Patients With Moderate Risk Mid Rectal Cancer(RuCorT-02) | unknown | Phase 3 | 316 | Blokhin's Russian Cancer Research CenterOTHER | 1 | Feb 9, 2021 | clinicaltrials |
| NCT04135313 | Induction and Consolidation Chemotherapy in Patients With Locally Advanced CRM-positive Rectal Cancer(RuCorT-03) | unknown | Phase 3 | 540 | Blokhin's Russian Cancer Research CenterOTHER | 1 | Feb 9, 2021 | clinicaltrials |
| NCT01224392 | Simultaneous Integrated Boost Preoperative Radiotherapy for Rectum Cancer(RectumSIB) | completed | Phase 3 | 156 | Universitair Ziekenhuis BrusselOTHER | 1 | Dec 30, 2020 | clinicaltrials |
| NCT01500993 | Capecitabine in the Perioperative Treatment of Rectal Cancer(Rektum-III) | completed | Phase 3 | 401 | Universitätsmedizin MannheimOTHER | 1 | Nov 27, 2020 | clinicaltrials |
| NCT04642924 | SGM-101 in Locally Advanced and Recurrent Rectal Cancer(SGM-LARRC) | unknown | Phase 2 / Phase 3 | 203 | Leiden University Medical CenterOTHER | 1 | Nov 24, 2020 | clinicaltrials |
| NCT02371304 | Rectal Preserving Treatment for Early Rectal Cancer. A Multi-centred Randomised Trial of Radical Surgery Versus Adjuvant Chemoradiotherapy After Local Excision for Early Rectal Cancers(TESAR) | unknown | Phase 3 | 302 | Amsterdam UMC, location VUmcOTHER | 1 | May 21, 2020 | clinicaltrials |
| NCT00207831 | Trial Testing Ftorafur (UFT) Associated With Neoadjuvant Radiotherapy Versus Radiotherapy Alone in Rectal Adenocarcinoma(UFT RT Phase 3) | terminated | Phase 3 | 219 | Institut Cancerologie de l'OuestOTHER | 1 | Mar 25, 2020 | clinicaltrials |
| NCT02928692 | Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium(MAPOCD) | unknown | Phase 3 | 750 | RenJi HospitalOTHER | 1 | Jan 28, 2020 | clinicaltrials |
| NCT02736942 | COLOR III Trial: Transanal vs Laparoscopic TME(COLORIII) | unknown | Phase 3 | 1,104 | Amsterdam UMC, location VUmcOTHER | 1 | Jun 6, 2019 | clinicaltrials |
| NCT03975049 | Triplet Combination or Doublet Regimen Versus Chemoradiation as Neoadjuvant Therapy for Locally Advanced Rectal Cancer | not yet recruiting | Phase 3 | 933 | Sixth Affiliated Hospital, Sun Yat-sen UniversityOTHER | 0 | Jun 5, 2019 | clinicaltrials |
| NCT03671252 | Prospectively Randomized Control Clinical Trial of FOLFOXIRI Preoperative Chemotherapy Alone on Rectal Cancer in Local Advance Comparing to Oral Capecitabine Combined With Long-term Radiation | recruiting | Phase 3 | 776 | Sun Yat-sen UniversityOTHER | 1 | Jan 23, 2019 | clinicaltrials |
| NCT00068692 | Comparison of Adjuvant Chemotherapy Regimens in Treating Stage II/III Rectal Cancer | completed | Phase 3 | 225 | National Cancer Institute (NCI)NIH | 1 | Dec 4, 2018 | clinicaltrials |
| NCT00254436 | A Double-Blind, Randomized, Placebo-Controlled Study of the Efficacy and Safety of Weekly Procrit Given to Gastric or Rectal Patients | terminated | Phase 3 | 50 | M.D. Anderson Cancer CenterOTHER | 1 | Oct 25, 2018 | clinicaltrials |
| NCT02127645 | Neoadjuvant Radiotherapy Followed by Transanal Endoscopic Microsurgery for T1-T2 Extraperitoneal Rectal Cancer(NERATEM) | completed | Phase 3 | 25 | European Association for Endoscopic SurgeryOTHER | 1 | Jul 26, 2018 | clinicaltrials |
| NCT02907385 | Efficacy and Safety of LifeSeal™ Kit for Colorectal Staple Line Sealing | unknown | Phase 3 | 736 | LifeBond Ltd.INDUSTRY | 7 | Mar 30, 2018 | clinicaltrials |
| NCT03431428 | Comparison of Short-term Efficacy and Long-term Prognosis for Reduction Surgery and Radical Resection in Almost-cCR Rectal Cancer Patients | unknown | Phase 3 | 477 | Zhang RuiOTHER | 1 | Feb 13, 2018 | clinicaltrials |
| NCT02163187 | Sacral Neuromodulation (SNM) With InterStimTM for Bowel Dysfunction Following Surgery for Rectal Cancers With Sphincter Preservation | terminated | Phase 2 / Phase 3 | 4 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Feb 5, 2018 | clinicaltrials |
| NCT00911170 | PAVES: Pegfilgrastim Anti-vascular Endothelial Growth Factor (VEGF) Evaluation Study | completed | Phase 3 | 847 | AmgenINDUSTRY | 17 | Dec 29, 2017 | clinicaltrials |
| NCT03242187 | Trans-anal Versus Laparoscopic TME for Mid and Low Rectal Cancer(MansTaTME) | unknown | Phase 2 / Phase 3 | 30 | Mansoura UniversityOTHER | 1 | Aug 8, 2017 | clinicaltrials |
Data updated 22 days agoSource updated Jun 13, 2025source: clinicaltrials