Malignant Musculoskeletal Neoplasm

Loading cancer entity…

Metric	Scope	Rank / eligible	Δ	Value	Percentile	Confidence	Formula	Generated	Inputs
Curated clinical evidence items	World · both sexes · all ages · latest · all malignant entities	#86 / 492	=	46 count	82.7	Medium confidence	ci-civic-evidence-v1	Sep 30, 2026	show formula: COUNT(civic_evidence_items) WHERE status = ACCEPTED AND cancer_id IN descendants(cancer) counter evidenceCount computedAt 2026-09-30T06:00:02.308Z inputs hash 00ec4259c26ee135c931f5a6 Trace lineage (admin)
Genes with curated or cohort evidence	World · both sexes · all ages · latest · all malignant entities	#211 / 521	=	14 count	59.6	Medium confidence	ci-genes-v1	Sep 30, 2026	show formula: COUNT(DISTINCT gene) FROM (civic accepted evidence ∪ gdc frequency ≥ 0.05 AND cases_affected ≥ 20) counter geneCount computedAt 2026-09-30T06:00:02.308Z inputs hash dc02edfbbd5b601934401df4 Trace lineage (admin)
Public genomic cohorts	World · both sexes · all ages · latest · all malignant entities	#172 / 296	=	4 count	42	Medium confidence	ci-cohorts-v1	Sep 30, 2026	show formula: COUNT(genomic_cohorts) WHERE cancer_id IN descendants(cancer) counter cohortCount computedAt 2026-09-30T06:00:02.308Z inputs hash 401b2e31f9813fbae9c90ab7 Trace lineage (admin)
Trial registration growth (year over year)	World · both sexes · all ages · latest · all malignant entities	#178 / 186	=	-0.28 ratio	4.3	Medium confidence	ci-trial-growth-v1	Sep 30, 2026	show formula: (new_trials_12m − new_trials_prior_12m) / new_trials_prior_12m (first_posted_date windows; interventional; descendants) asOf 2026-09-30 windows new12m to 2026-09-30 from 2025-09-30 prior12m to 2025-09-30 from 2024-09-30 studyType INTERVENTIONAL aggregation descendants
Active clinical trials	World · both sexes · all ages · latest · all malignant entities	#163 / 1,654	=	141 count	90.2	Medium confidence	ci-active-trials-v1	Sep 30, 2026	show formula: COUNT(DISTINCT trial) FROM trial_conditions JOIN clinical_trials WHERE cancer_id IN descendants(cancer) AND study_type = INTERVENTIONAL AND overall_status IN (RECRUITING, NOT_YET_RECRUITING, ENROLLING_BY_INVITATION, ACTIVE_NOT_RECRUITING) counter activeTrialCount computedAt 2026-09-30T06:00:02.308Z inputs hash d8f333d5bfdbadb41c05f9e2 Trace lineage (admin)
Active Phase III trials	World · both sexes · all ages · latest · all malignant entities	#193 / 810	=	10 count	76.3	Medium confidence	ci-phase3-trials-v1	Sep 30, 2026	show formula: COUNT(DISTINCT trial) … active statuses AND PHASE3 = ANY(phases) counter phase3TrialCount computedAt 2026-09-30T06:00:02.308Z inputs hash 55bad1a93f2cbb5682249863 Trace lineage (admin)
Recruiting clinical trials	World · both sexes · all ages · latest · all malignant entities	#166 / 1,284	=	73 count	87.1	Medium confidence	ci-recruiting-trials-v1	Sep 30, 2026	show formula: COUNT(DISTINCT trial) … overall_status = RECRUITING AND study_type = INTERVENTIONAL counter recruitingTrialCount computedAt 2026-09-30T06:00:02.308Z inputs hash 00002505dcded3e0217a182d Trace lineage (admin)
Recruiting Phase III trials	World · both sexes · all ages · latest · all malignant entities	#180 / 585	=	6 count	69.3	High confidence	ci-phase3-recruiting-v1	Sep 30, 2026	show formula: COUNT(DISTINCT trial) … overall_status = RECRUITING AND PHASE3 = ANY(phases) AND study_type = INTERVENTIONAL asOf 2026-09-30 studyType INTERVENTIONAL aggregation descendants activeTrials 141 activeStatuses RECRUITING NOT_YET_RECRUITING ENROLLING_BY_INVITATION ACTIVE_NOT_RECRUITING formulaVersion ci-trial-intel-v1 phase3Recruiting 6 inputs hash 3f7191c10405ddd12eec0cad Trace lineage (admin)
Sponsor concentration (HHI)	World · both sexes · all ages · latest · all malignant entities	#396 / 614	=	0.035 index (0–1)	35.6	High confidence	ci-sponsor-hhi-v1	Sep 30, 2026	show formula: Σ (active_trials_by_lead_sponsor / active_trials)² over the cancer and its descendants asOf 2026-09-30 studyType INTERVENTIONAL topSponsor National Cancer Institute (NCI) aggregation descendants activeTrials 141 activeStatuses RECRUITING NOT_YET_RECRUITING ENROLLING_BY_INVITATION ACTIVE_NOT_RECRUITING formulaVersion ci-trial-intel-v1 minActiveTrials 10 topSponsorShare
Trial termination share	World · both sexes · all ages · latest · all malignant entities	#331 / 454	=	0.31 ratio	27.2	High confidence	ci-trial-termination-v1	Sep 30, 2026	show formula: (terminated + withdrawn) / (completed + terminated + withdrawn) WHERE first_posted_date ≥ 2010-01-01 AND study_type = INTERVENTIONAL asOf 2026-09-30 since 2010-01-01 terminal 149 completed 103 studyType INTERVENTIONAL withdrawn 13 terminated 33 aggregation descendants activeStatuses RECRUITING NOT_YET_RECRUITING ENROLLING_BY_INVITATION ACTIVE_NOT_RECRUITING

Metric

Scope

Rank / eligible

Value

Percentile

Confidence

Formula

Generated

Inputs

Curated clinical evidence items

World · both sexes · all ages · latest · all malignant entities

#86 / 492

46 count

82.7

Medium confidence

ci-civic-evidence-v1

Sep 30, 2026

show

formula: COUNT(civic_evidence_items) WHERE status = ACCEPTED AND cancer_id IN descendants(cancer)

counter: evidenceCount
computedAt: 2026-09-30T06:00:02.308Z

inputs hash 00ec4259c26ee135c931f5a6

Trace lineage (admin)

Genes with curated or cohort evidence

World · both sexes · all ages · latest · all malignant entities

#211 / 521

14 count

59.6

Medium confidence

ci-genes-v1

Sep 30, 2026

show

formula: COUNT(DISTINCT gene) FROM (civic accepted evidence ∪ gdc frequency ≥ 0.05 AND cases_affected ≥ 20)

counter: geneCount
computedAt: 2026-09-30T06:00:02.308Z

inputs hash dc02edfbbd5b601934401df4

Trace lineage (admin)

Public genomic cohorts

World · both sexes · all ages · latest · all malignant entities

#172 / 296

4 count

Medium confidence

ci-cohorts-v1

Sep 30, 2026

show

formula: COUNT(genomic_cohorts) WHERE cancer_id IN descendants(cancer)

counter: cohortCount
computedAt: 2026-09-30T06:00:02.308Z

inputs hash 401b2e31f9813fbae9c90ab7

Trace lineage (admin)

Trial registration growth (year over year)

World · both sexes · all ages · latest · all malignant entities

#178 / 186

-0.28 ratio

4.3

Medium confidence

ci-trial-growth-v1

Sep 30, 2026

show

formula: (new_trials_12m − new_trials_prior_12m) / new_trials_prior_12m (first_posted_date windows; interventional; descendants)

asOf

2026-09-30

windows

new12m

to: 2026-09-30
from: 2025-09-30

prior12m

to: 2025-09-30
from: 2024-09-30

studyType

INTERVENTIONAL

aggregation

descendants

Active clinical trials

World · both sexes · all ages · latest · all malignant entities

#163 / 1,654

141 count

90.2

Medium confidence

ci-active-trials-v1

Sep 30, 2026

show

formula: COUNT(DISTINCT trial) FROM trial_conditions JOIN clinical_trials WHERE cancer_id IN descendants(cancer) AND study_type = INTERVENTIONAL AND overall_status IN (RECRUITING, NOT_YET_RECRUITING, ENROLLING_BY_INVITATION, ACTIVE_NOT_RECRUITING)

counter: activeTrialCount
computedAt: 2026-09-30T06:00:02.308Z

inputs hash d8f333d5bfdbadb41c05f9e2

Trace lineage (admin)

Active Phase III trials

World · both sexes · all ages · latest · all malignant entities

#193 / 810

10 count

76.3

Medium confidence

ci-phase3-trials-v1

Sep 30, 2026

show

formula: COUNT(DISTINCT trial) … active statuses AND PHASE3 = ANY(phases)

counter: phase3TrialCount
computedAt: 2026-09-30T06:00:02.308Z

inputs hash 55bad1a93f2cbb5682249863

Trace lineage (admin)

Recruiting clinical trials

World · both sexes · all ages · latest · all malignant entities

#166 / 1,284

73 count

87.1

Medium confidence

ci-recruiting-trials-v1

Sep 30, 2026

show

formula: COUNT(DISTINCT trial) … overall_status = RECRUITING AND study_type = INTERVENTIONAL

counter: recruitingTrialCount
computedAt: 2026-09-30T06:00:02.308Z

inputs hash 00002505dcded3e0217a182d

Trace lineage (admin)

Recruiting Phase III trials

World · both sexes · all ages · latest · all malignant entities

#180 / 585

6 count

69.3

High confidence

ci-phase3-recruiting-v1

Sep 30, 2026

show

formula: COUNT(DISTINCT trial) … overall_status = RECRUITING AND PHASE3 = ANY(phases) AND study_type = INTERVENTIONAL

asOf: 2026-09-30
studyType: INTERVENTIONAL
aggregation: descendants
activeTrials: 141
activeStatuses: RECRUITING
NOT_YET_RECRUITING
ENROLLING_BY_INVITATION
ACTIVE_NOT_RECRUITING
formulaVersion: ci-trial-intel-v1
phase3Recruiting: 6

inputs hash 3f7191c10405ddd12eec0cad

Trace lineage (admin)

Sponsor concentration (HHI)

World · both sexes · all ages · latest · all malignant entities

#396 / 614

0.035 index (0–1)

35.6

High confidence

ci-sponsor-hhi-v1

Sep 30, 2026

show

formula: Σ (active_trials_by_lead_sponsor / active_trials)² over the cancer and its descendants

asOf: 2026-09-30
studyType: INTERVENTIONAL
topSponsor: National Cancer Institute (NCI)
aggregation: descendants
activeTrials: 141
activeStatuses: RECRUITING
NOT_YET_RECRUITING
ENROLLING_BY_INVITATION
ACTIVE_NOT_RECRUITING
formulaVersion: ci-trial-intel-v1
minActiveTrials: 10
topSponsorShare

Trial termination share

World · both sexes · all ages · latest · all malignant entities

#331 / 454

0.31 ratio

27.2

High confidence

ci-trial-termination-v1

Sep 30, 2026

show

formula: (terminated + withdrawn) / (completed + terminated + withdrawn) WHERE first_posted_date ≥ 2010-01-01 AND study_type = INTERVENTIONAL

asOf: 2026-09-30
since: 2010-01-01
terminal: 149
completed: 103
studyType: INTERVENTIONAL
withdrawn: 13
terminated: 33
aggregation: descendants
activeStatuses: RECRUITING
NOT_YET_RECRUITING
ENROLLING_BY_INVITATION
ACTIVE_NOT_RECRUITING

Why this rank?

Research gap