Subtype
Malignant Large Intestinal Neoplasm
CI-CAN-00003173Explore in graph →
1,622 active trials21 approved drugs383 evidence items
- NCIt
- C215202
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Subtype
CI-CAN-00003173Explore in graph →
Clinical trials
7,502 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (742)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT01328171 | FOLFOXIRI With or Without Panitumumab in Metastatic Colorectal Cancer (VOLFI)(VOLFI) | completed | Phase 2 | 93 | AIO-Studien-gGmbHOTHER | 1 | Jun 15, 2023 | clinicaltrials |
| NCT01991873 | Maintenance Therapy With 5-FU/FA Plus Panitumumab vs. 5-FU/FA Alone After Prior Induction and Re-induction After Progress for 1st-line Treatment of Metastatic Colorectal Cancer(PanaMa) | completed | Phase 2 | 387 | AIO-Studien-gGmbHOTHER | 1 |
| Jun 15, 2023 |
| clinicaltrials |
| NCT03428126 | Study of Durvalumab (MEDI4736) (Anti-PD-L1) and Trametinib (MEKi) in MSS Metastatic Colon Cancer | completed | Phase 2 | 29 | M.D. Anderson Cancer CenterOTHER | 1 | Jun 15, 2023 | clinicaltrials |
| NCT02919969 | Pembrolizumab in Metastatic Anal Cancer | completed | Phase 2 | 38 | Dana-Farber Cancer InstituteOTHER | 1 | Jun 12, 2023 | clinicaltrials |
| NCT05025631 | A Phase II Study on Dose Optimization of Fruquintinib in Elderly mCRC Patients Refractory to Standard Treatment（DOFEMCRC）(DOFEMCRC) | completed | Phase 2 | 29 | Zhen-Yu DingOTHER | 1 | Apr 28, 2023 | clinicaltrials |
| NCT00093379 | Capecitabine, Oxaliplatin, and Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer | completed | Phase 2 | 20 | M.D. Anderson Cancer CenterOTHER | 1 | Apr 18, 2023 | clinicaltrials |
| NCT05816980 | Re-irradiation for Pelvic Recurrences in Rectal Cancer Patients(Re-RAD-I) | completed | Phase 2 | 16 | Aarhus University HospitalOTHER | 2 | Apr 18, 2023 | clinicaltrials |
| NCT03279289 | Study to Assess the Efficacy and Safety of Treatment With FOLFIRI-aflibercept Compared to Initial Treatment With FOLFIRI-aflibercept (for 6 Cycles) Followed by Maintenance With 5FU-aflibercept, in an Elderly Population With mCRC After Failure of an Oxaliplatin-based Regimen(AFEMA) | completed | Phase 2 | 170 | Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)OTHER | 1 | Apr 13, 2023 | clinicaltrials |
| NCT03427411 | M7824 in Subjects With HPV Associated Malignancies | completed | Phase 2 | 57 | National Cancer Institute (NCI)NIH | 1 | Mar 28, 2023 | clinicaltrials |
| NCT03770689 | Study of Peposertib in Combination With Capecitabine and RT in Rectal Cancer | completed | Phase 1 / Phase 2 | 19 | EMD Serono Research & Development Institute, Inc.INDUSTRY | 2 | Mar 21, 2023 | clinicaltrials |
| NCT03801915 | Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers | completed | Phase 2 | 10 | National Cancer Institute (NCI)NIH | 1 | Mar 21, 2023 | clinicaltrials |
| NCT02399813 | A Phase 2 Study of Axalimogene Filolisbac (ADXS11-001) in Participants With Carcinoma of the Anorectal Canal | completed | Phase 2 | 36 | Advaxis, Inc.INDUSTRY | 1 | Mar 20, 2023 | clinicaltrials |
| NCT03299660 | Avelumab With Chemoradiation in Locally Advanced Rectal Cancer | completed | Phase 2 | 37 | Peter MacCallum Cancer Centre, AustraliaOTHER | 1 | Mar 16, 2023 | clinicaltrials |
| NCT04224415 | Re-challenge of Anti-EGFR for Patients With RAS/BRAF Wild-type Metastatic CRC | completed | Phase 2 | 35 | Yuhong LiOTHER | 1 | Feb 15, 2023 | clinicaltrials |
| NCT03043729 | mFOLFOX6 vs. mFOLFOX6 + Aflibercept as Neoadjuvant Treatment in MRI-defined T3-rectal Cancer | completed | Phase 2 | 119 | AIO-Studien-gGmbHOTHER | 1 | Feb 6, 2023 | clinicaltrials |
| NCT04021589 | Chemotherapy w/wo WeiLeShu in Metastatic Colorectal Cancer | completed | Phase 2 | 40 | Zhejiang UniversityOTHER | 1 | Jan 30, 2023 | clinicaltrials |
| NCT02713529 | Safety and Efficacy Study of AMG 820 and Pembrolizumab Combination in Select Advanced Solid Tumor Cancer | completed | Phase 1 / Phase 2 | 117 | AmMax Bio, Inc.INDUSTRY | 6 | Jan 20, 2023 | clinicaltrials |
| NCT03458975 | Targeted Delivery of Chemotherapy With Ultrasound and Microbublles(SONCHIMIO) | completed | Phase 2 | 7 | University Hospital, ToursOTHER | 1 | Jan 9, 2023 | clinicaltrials |
| NCT02963831 | A Study to Investigate ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies | completed | Phase 1 / Phase 2 | 67 | Ludwig Institute for Cancer ResearchOTHER | 1 | Dec 22, 2022 | clinicaltrials |
| NCT04009876 | A Study to Evaluate a Chemotherapy Treatment Followed by Chemo and Radiotherapy in Patients With Rectal Cancer | completed | Phase 2 | 30 | Fundación de investigación HMOTHER | 1 | Dec 13, 2022 | clinicaltrials |
| NCT04591379 | Intratumoral Influenza Vaccine for Early Colorectal Cancer | completed | Phase 2 | 10 | Zealand University HospitalOTHER | 1 | Dec 13, 2022 | clinicaltrials |
| NCT01874860 | Skin Rash Study Before Chemotherapy in Colorectal & Head and Neck Cancer Patients | completed | Phase 2 | 24 | University of LouisvilleOTHER | 1 | Dec 1, 2022 | clinicaltrials |
| NCT05622357 | Prospective Study of Short Course Radiation Therapy Followed by Neoadjuvant Chemotherapy and Surgery in Locally Advanced Rectal Cancer | completed | Phase 2 | 51 | National Cancer Institute, EgyptOTHER | 1 | Nov 18, 2022 | clinicaltrials |
| NCT01326000 | A Study of RO5083945 in Combination With FOLFIRI Versus FOLFIRI Plus Cetuximab or FOLFIRI Alone as Second Line Treatment in Patients With Metastatic Colorectal Cancer | completed | Phase 2 | 169 | Hoffmann-La RocheINDUSTRY | 9 | Nov 17, 2022 | clinicaltrials |
| NCT00089635 | Panitumumab (ABX-EGF) Monotherapy in Patients With Metastatic Colorectal Cancer | completed | Phase 2 | 203 | AmgenINDUSTRY | 0 | Nov 7, 2022 | clinicaltrials |
| NCT00467142 | Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery(OMEGA) | completed | Phase 2 | 62 | Institut BergoniéOTHER | 1 | Nov 1, 2022 | clinicaltrials |
| NCT02713373 | Cetuximab and Pembrolizumab in Treating Patients With Colorectal Cancer That is Metastatic or Cannot Be Removed by Surgery | completed | Phase 1 / Phase 2 | 45 | Roswell Park Cancer InstituteOTHER | 1 | Oct 6, 2022 | clinicaltrials |
| NCT03174405 | Avelumab and Cetuximab in Combination With FOLFOX in Patients With Previously Untreated Metastatic Colorectal Cancer - The Phase II AVETUX-CRC Trial.(AVETUX) | completed | Phase 2 | 43 | AIO-Studien-gGmbHOTHER | 1 | Sep 29, 2022 | clinicaltrials |
| NCT03965845 | A Study of Telaglenastat (CB-839) in Combination With Palbociclib in Patients With Solid Tumors | completed | Phase 1 / Phase 2 | 53 | Calithera Biosciences, IncINDUSTRY | 1 | Sep 19, 2022 | clinicaltrials |
| NCT03227926 | Rechallenge With Panitumumab Driven by RAS Dynamic of Resistance(CHRONOS) | completed | Phase 2 | 32 | Fondazione del Piemonte per l'OncologiaOTHER | 1 | Aug 25, 2022 | clinicaltrials |
| NCT01064375 | Safety Study of DNA Vaccine Delivered by Intradermal Electroporation to Treat Colorectal Cancer(El-porCEA) | completed | Phase 1 / Phase 2 | 16 | Maria LiljeforsOTHER | 1 | Aug 19, 2022 | clinicaltrials |
| NCT02569645 | Rosuvastatin in the Treatment of Rectal Cancer | completed | Phase 2 | 45 | AHS Cancer Control AlbertaOTHER | 1 | Jul 20, 2022 | clinicaltrials |
| NCT03542877 | Investigating Cabozantinib in Patients With Refractory Metastatic Colorectal Cancer | completed | Phase 2 | 44 | Academic Thoracic Oncology Medical Investigators ConsortiumINDUSTRY | 1 | Jul 15, 2022 | clinicaltrials |
| NCT04080843 | Anlotinib Hydrochloride Capsules Combined With CAPEOX in RAS and BRAF Wild-type mCRC Patients(ALTER-C-002) | completed | Phase 2 | 30 | Zhejiang UniversityOTHER | 1 | Jul 13, 2022 | clinicaltrials |
| NCT03122509 | A Clinical Trial of Durvalumab and Tremelimumab, Administered With Radiation Therapy or Ablation in Patients With Colorectal Cancer | completed | Phase 2 | 25 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Jul 6, 2022 | clinicaltrials |
| NCT05414461 | Efficacy of Combination Immunotherapy in Patients With Metastatic Colorectal Cancer | completed | Phase 2 | 97 | First Affiliated Hospital of Zhejiang UniversityOTHER | 1 | Jun 10, 2022 | clinicaltrials |
| NCT03332498 | Pembrolizumab in Combination With Ibrutinib for Advanced, Refractory Colorectal Cancers | completed | Phase 1 / Phase 2 | 40 | H. Lee Moffitt Cancer Center and Research InstituteOTHER | 1 | Jun 3, 2022 | clinicaltrials |
| NCT03101475 | Synergism of Immunomodulation and Tumor Ablation(ILOC) | completed | Phase 2 | 22 | European Organisation for Research and Treatment of Cancer - EORTCNETWORK | 6 | May 31, 2022 | clinicaltrials |
| NCT03391232 | PolyPEPI1018 Vaccine and CDx for the Treatment of Metastatic Colorectal Cancer (OBERTO)(OBERTO) | completed | Phase 1 / Phase 2 | 11 | Treos Bio ZrtINDUSTRY | 2 | May 26, 2022 | clinicaltrials |
| NCT02399943 | A Trial of Trametinib and Panitumumab in RAS/RAF Wild Type Advanced Colorectal Cancer | completed | Phase 2 | 14 | University Health Network, TorontoOTHER | 1 | May 16, 2022 | clinicaltrials |
| NCT02402842 | Clinical and Biological Interest of Taxanes in Advanced Squamous Cell Anal Carcinoma(Epitopes-HPV02) | completed | Phase 2 | 70 | Centre Hospitalier Universitaire de BesanconOTHER | 1 | May 16, 2022 | clinicaltrials |
| NCT04561336 | Avelumab Plus Cetuximab in Pre-treated RAS Wild Type Metastatic Colorectal Cancer | completed | Phase 2 | 77 | University of Campania Luigi VanvitelliOTHER | 1 | May 5, 2022 | clinicaltrials |
| NCT03666442 | Early Evaluation of Chemosensitivity for Low/Intermediated-risk Mid-low Stage II/III Rectal Cancer | completed | Phase 2 | 61 | West China HospitalOTHER | 1 | Apr 29, 2022 | clinicaltrials |
| NCT01516216 | Study of Vitamin D in Untreated Metastatic Colorectal Cancer | completed | Phase 2 | 139 | Dana-Farber Cancer InstituteOTHER | 1 | Apr 26, 2022 | clinicaltrials |
| NCT03102047 | Study of Durvalumab (MEDI4736) After Chemo-Radiation for Microsatellite Stable Stage II-IV Rectal Cancer | completed | Phase 2 | 45 | NSABP Foundation IncNETWORK | 1 | Apr 20, 2022 | clinicaltrials |
| NCT03799731 | Study for Evaluation of Murlentamab (GM102) Anti-tumoral Activity in Colorectal Cancers | completed | Phase 2 | 65 | GamaMabs PharmaINDUSTRY | 2 | Apr 14, 2022 | clinicaltrials |
| NCT04425239 | Intermittent or Continuous Panitumumab Plus FOLFIRI for RAS/B-RAF Wild-type Metastatic Colorectal Cancer(IMPROVE) | completed | Phase 2 | 151 | National Cancer Institute, NaplesOTHER | 1 | Apr 7, 2022 | clinicaltrials |
| NCT05316818 | Triplet (FOLFOXIRI) vs. Doublet (FOLFOX or FOLFIRI) Regimen as a 1st Line Treatment in Metastatic Colorectal Carcinoma | completed | Phase 2 | 64 | Kasr El Aini HospitalOTHER | 1 | Apr 7, 2022 | clinicaltrials |
| NCT03832621 | NIVOLUMAB Plus IPILIMUMAB and TEMOZOLOMIDE in Microsatellite Stable, MGMT Silenced Metastatic Colorectal Cancer(MAYA) | completed | Phase 2 | 135 | Fondazione IRCCS Istituto Nazionale dei Tumori, MilanoOTHER | 1 | Apr 4, 2022 | clinicaltrials |
Data updated 23 days agoSource updated Jun 15, 2023source: clinicaltrials