Cancer
Malignant Esophageal Neoplasm
CI-CAN-00001127Explore in graph →
Top-level518 active trials6 approved drugs12 evidence items
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Cancer
CI-CAN-00001127Explore in graph →
Clinical trials
1,926 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (169)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT06863831 | A Multicenter Trial of YSQTG vs. Simulated Agents With Neoadjuvant Chemoradiotherapy or Chemoimmunotherapy for EC | enrolling by invitation | N/A | 536 | Cancer Institute and Hospital, Chinese Academy of Medical SciencesOTHER | 1 | Mar 7, 2025 | clinicaltrials |
| NCT04460352 | Chemoradiotherapy Followed by Planned Surgery or by Surveillance and Surgery Only When Needed for Oesophageal Cancer(NEEDS) | recruiting | Phase 3 | 1,020 | Karolinska University HospitalOTHER |
| 5 |
| Mar 6, 2025 |
| clinicaltrials |
| NCT05697198 | PRospective REgistry of Advanced Stage CancER (PREFER) Patients to Assess Prevalence of Actionable Biomarkers and Driver Mutations to Address Disparities in Precision Medicine(PREFER) | completed | — | 1,429 | Labcorp Corporation of America Holdings, IncINDUSTRY | 1 | Mar 6, 2025 | clinicaltrials |
| NCT05865743 | Perioperative SDD to Prevent Infectious Complications After Esophagectomy(PERSuaDER) | recruiting | Phase 3 | 854 | Radboud University Medical CenterOTHER | 2 | Mar 5, 2025 | clinicaltrials |
| NCT03937362 | Pre-Surgery If Needed for Oesophageal Cancer(preSINO) | completed | — | 200 | Shanghai Chest HospitalOTHER | 4 | Mar 3, 2025 | clinicaltrials |
| NCT02634645 | TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus) | recruiting | — | 5,000 | University of Colorado, DenverOTHER | 1 | Feb 28, 2025 | clinicaltrials |
| NCT06852456 | QL1706 in Combination With Neoadjuvant Chemotherapy Versus Neoadjuvant Chemotherapy for Locally Advanced, Resectable Esophageal Squamous Cell Carcinoma | not yet recruiting | Phase 2 | 30 | Qilu Pharmaceutical Co., Ltd.INDUSTRY | 0 | Feb 28, 2025 | clinicaltrials |
| NCT06168825 | Mind Over Matter for Black and African American Women: A Single Arm Trial Examining Feasibility and Acceptability of a Supportive Intervention(MOM) | completed | — | 40 | Inova Health Care ServicesOTHER | 1 | Feb 27, 2025 | clinicaltrials |
| NCT06713421 | Effect of Premedication With Pronase on Mucosal Cleanliness During EGD | recruiting | N/A | 3,000 | Changhai HospitalOTHER | 1 | Feb 25, 2025 | clinicaltrials |
| NCT04804696 | Toripalimab with Paclitaxel and Cisplatin As Neoadjuvant Treatment for Esophageal Squamous Cell Carcinoma | terminated | Phase 2 | 10 | Peking UniversityOTHER | 1 | Feb 21, 2025 | clinicaltrials |
| NCT06440018 | INSPIRE: a Multi-Cancer Early Detection Study(INSPIRE) | unknown | — | 5,350 | Singlera Genomics Inc.INDUSTRY | 1 | Feb 21, 2025 | clinicaltrials |
| NCT06833775 | Evaluation of Neoadjuvant Therapy Efficacy and Postoperative Pathological Indicators in Esophageal Cancer Using CT and Multimodal MRI | not yet recruiting | — | 400 | Henan Cancer HospitalOTHER_GOV | 0 | Feb 20, 2025 | clinicaltrials |
| NCT06289374 | Longitudinal Assessment of Biomarkers After Oesophagogastric Cancer Surgery(LABS) | recruiting | — | 100 | Imperial College LondonOTHER | 1 | Feb 19, 2025 | clinicaltrials |
| NCT06829095 | Personalized Nutrition Counseling and Nutritional Status of Esophageal Cancer and HNSCC Patients Undergoing CCRT | recruiting | — | 90 | Chang Gung Memorial HospitalOTHER | 1 | Feb 17, 2025 | clinicaltrials |
| NCT06828718 | The Neoadjuvant Treatment Modalities in Patients With Locally Advanced Esophageal Squamous Cell Carcinoma (NEO-EC)(NEO-EC) | active not recruiting | — | 1,000 | Hebei Medical University Fourth HospitalOTHER | 1 | Feb 14, 2025 | clinicaltrials |
| NCT05191667 | AN0025 and Chemoradiotherapy Combination in Esophageal Cancer | suspended | Phase 1 | 32 | Adlai Nortye Biopharma Co., Ltd.INDUSTRY | 1 | Feb 13, 2025 | clinicaltrials |
| NCT05491616 | Nivolumab During Active Surveillance After Neoadjuvant Chemoradiation for Esophageal Cancer: SANO-3 Study(SANO-3) | active not recruiting | Phase 2 | 77 | Erasmus Medical CenterOTHER | 1 | Feb 13, 2025 | clinicaltrials |
| NCT06818214 | Mechanistic Study on the Diagnosis of Esophageal Cancer Lymph Node Metastasis Using Spectral CT, Multimodal MRI, FAPI PET-CT, Pathology, and AI Evaluation System | not yet recruiting | — | 400 | Henan Cancer HospitalOTHER_GOV | 0 | Feb 10, 2025 | clinicaltrials |
| NCT02349412 | Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers | completed | Phase 3 | 405 | Alliance for Clinical Trials in OncologyOTHER | 1 | Feb 7, 2025 | clinicaltrials |
| NCT06702384 | Molecular Analysis of Gastric and OEsophageal Cancers STudy(MAGnET) | withdrawn | — | 0 | Royal Marsden NHS Foundation TrustOTHER | 1 | Feb 6, 2025 | clinicaltrials |
| NCT04732494 | Anti-PD-1 Monoclonal Antibody Tislelizumab (BGB-A317) Combined With or Without Anti-TIGIT Monoclonal Antibody Ociperlimab (BGB-A1217) in Participants With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma(AdvanTIG-203) | completed | Phase 2 | 125 | BeiGeneINDUSTRY | 6 | Jan 31, 2025 | clinicaltrials |
| NCT05431621 | Establishment of Molecular Classification Models for Early Diagnosis of Digestive System Cancers | completed | — | 2,430 | Shanghai Zhongshan HospitalOTHER | 1 | Jan 29, 2025 | clinicaltrials |
| NCT05937438 | Postoperative Radiotherapy Followed by Immunotherapy for Locally Advanced Esophageal Carcinoma | recruiting | Phase 1 / Phase 2 | 70 | Anhui Provincial HospitalOTHER_GOV | 1 | Jan 29, 2025 | clinicaltrials |
| NCT05462314 | Intestinal Microbiome, Oral Microbiome, and Whole Blood Transcriptome Analyses in Gastrointestinal Malignancies | completed | — | 24 | ViomeINDUSTRY | 1 | Jan 28, 2025 | clinicaltrials |
| NCT03154190 | Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With Cancer | completed | N/A | 128 | Stanford UniversityOTHER | 1 | Jan 24, 2025 | clinicaltrials |
| NCT05944809 | The Effect of Prophylactic TPO Combined with BMS-IMRT to Esophageal Cancer Patients | completed | Phase 2 | 32 | JIANYANG WANGOTHER | 1 | Jan 24, 2025 | clinicaltrials |
| NCT06306755 | Effectiveness of Risk-based Sequential Screening for Esophageal and Gastric Cancer(ERSS-EGC) | recruiting | N/A | 21,000 | Peking University Cancer Hospital & InstituteOTHER | 1 | Jan 24, 2025 | clinicaltrials |
| NCT06790797 | Investigating the Biomarkers in Tumor and Peripheral Blood to Evaluate the Efficacy of Cancer Immunotherapy in Chest Cancer Patients | recruiting | — | 50 | Zhao JunOTHER | 1 | Jan 24, 2025 | clinicaltrials |
| NCT04499924 | Tucatinib, Trastuzumab, Ramucirumab, and Paclitaxel Versus Paclitaxel and Ramucirumab in Previously Treated HER2+ Gastroesophageal Cancer(MOUNTAINEER-02) | completed | Phase 2 / Phase 3 | 17 | Seagen Inc.INDUSTRY | 6 | Jan 22, 2025 | clinicaltrials |
| NCT06489197 | AK112 Combined With Chemotherapy as the First-line Treatment in Advanced Esophageal Squamous Cell Carcinoma Patients | recruiting | Phase 2 | 30 | Tianjin Medical University Cancer Institute and HospitalOTHER | 1 | Jan 22, 2025 | clinicaltrials |
| NCT06787807 | Proteomic Analysis of Patients Undergoing Bariatric Surgery | not yet recruiting | N/A | 103 | Universidade Federal de PernambucoOTHER | 1 | Jan 22, 2025 | clinicaltrials |
| NCT06775652 | Neoadjuvant Chemoradiotherapy Plus Surgery vs. Surgery Plus Adjuvant Therapy for ESCC(ESCC) | completed | Phase 3 | 254 | Yongtao HanOTHER | 1 | Jan 15, 2025 | clinicaltrials |
| NCT06760676 | A Multiple Tumor Species, Open and Multi-center Clinical Study of Alpaloritovorelli Antibodies (QL-1706) Combined with Pulsed Low Dose Rate External Irradiation (PLDR) for Disease Progression After Previous Anti-tumor Therapy | not yet recruiting | Phase 1 | 90 | Anhui Provincial HospitalOTHER_GOV | 0 | Jan 7, 2025 | clinicaltrials |
| NCT06762158 | NCRT Combined With Sequential Perioperative PD-1 Inhibitor for LAESCC | active not recruiting | N/A | 50 | RenJi HospitalOTHER | 1 | Jan 7, 2025 | clinicaltrials |
| NCT06756841 | Safety and Efficacy Study of Pulsed Electric Field (PEF) Therapy in Patients With Advanced or Unresectable Esophageal Squamous Cell Carcinoma | not yet recruiting | N/A | 10 | Energenx Medical LTD.INDUSTRY | 1 | Jan 3, 2025 | clinicaltrials |
| NCT05007613 | Second-line Cabozantinib and Atezolizumab in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma | completed | Phase 2 | 24 | National Taiwan University HospitalOTHER | 1 | Jan 1, 2025 | clinicaltrials |
| NCT06755866 | DCE-MRI Based on 4D Free Breathing for Predicting Preoperative Neoadjuvant Chemoradiotherapy for Esophageal Cancer | recruiting | N/A | 135 | Yunnan Cancer HospitalOTHER | 1 | Jan 1, 2025 | clinicaltrials |
| NCT05214222 | Penpulimab Plus Chemotherapy With/Without Anlotinib for Patients With Advanced Esophageal Squamous Cell Carcinoma(ANSWER) | recruiting | Phase 2 | 100 | Nanfang Hospital, Southern Medical UniversityOTHER | 1 | Dec 30, 2024 | clinicaltrials |
| NCT05500508 | Oral AMXT 1501 Dicaprate in Combination With IV DFMO | terminated | Phase 1 / Phase 2 | 15 | Aminex Therapeutics, Inc.INDUSTRY | 2 | Dec 24, 2024 | clinicaltrials |
| NCT06746961 | Efficacy and Safety of QL1706 Plus Lenvatinib As 2nd Line Theapy in Patients with Metastatic Esophageal Carcinoma After Disease Progression on ICIs Therapy | not yet recruiting | Phase 1 / Phase 2 | 49 | The First Affiliated Hospital of Zhengzhou UniversityOTHER | 0 | Dec 24, 2024 | clinicaltrials |
| NCT06745193 | A Prospective, Randomized, Open, Phase II Clinical Study of Chidamide in Combination with Camrelizumab and Apatinib for Advanced Esophageal Cancer | not yet recruiting | Phase 2 | 63 | Peking UniversityOTHER | 1 | Dec 20, 2024 | clinicaltrials |
| NCT04028479 | The Registry of Oncology Outcomes Associated With Testing and Treatment(ROOT) | completed | — | 167 | Taproot HealthINDUSTRY | 1 | Dec 18, 2024 | clinicaltrials |
| NCT05055648 | PROton Versus Photon Therapy for Esophageal Cancer - a Trimodality Strategy(PROTECT) | recruiting | Phase 3 | 396 | University of AarhusOTHER | 8 | Dec 17, 2024 | clinicaltrials |
| NCT03518554 | A First in Human, Dose Escalation Study of JAB-3068 (SHP2 Inhibitor) in Adult Patients With Advanced Solid Tumors | completed | Phase 1 | 38 | Jacobio Pharmaceuticals Co., Ltd.INDUSTRY | 1 | Dec 16, 2024 | clinicaltrials |
| NCT04278287 | Chemoradiotherapy in Unresectable Esophageal Cancer | recruiting | Phase 1 / Phase 2 | 105 | Cancer Institute and Hospital, Chinese Academy of Medical SciencesOTHER | 1 | Dec 13, 2024 | clinicaltrials |
| NCT04212598 | The Value of Sintilimab Consolidation Therapy After Definitive Concurrent Chemoradiotherapy for Locally Advanced Thoracic Esophageal Cancer | completed | Phase 2 | 40 | Wuhan UniversityOTHER | 1 | Dec 10, 2024 | clinicaltrials |
| NCT06019455 | The Level of Patient Participation in Lung and Esophageal Cancer Patients Treated With Definitive Radiochemotherapy. | recruiting | — | 500 | Sun Yat-sen UniversityOTHER | 1 | Dec 10, 2024 | clinicaltrials |
| NCT06722300 | Clinical Study on the Impact of Eradication of Oral Porphyromonas Gingivalis on the Prognosis of Early Esophageal Cancer After ESD Surgery | active not recruiting | N/A | 856 | The First Affiliated Hospital of Henan University of Science and TechnologyOTHER | 1 | Dec 9, 2024 | clinicaltrials |
| NCT06718205 | Nimotuzumab Combined With Sintilimab and Chemotherapy for Advanced Esophageal Squamous Cell Carcinoma | recruiting | Phase 2 | 112 | The First Affiliated Hospital of Zhengzhou UniversityOTHER | 1 | Dec 5, 2024 | clinicaltrials |
Data updated 24 days agoSource updated Mar 7, 2025source: clinicaltrials