Malignant Adrenal Gland Neoplasm — Variants & evidence

Malignant Adrenal Gland Neoplasm — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

2 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items (2 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
High1
Ipilimumab + Lenvatinib + PembrolizumabCombination	Adrenal Cortical CarcinomaALIAS	Predictive	C	Supports Sensitivity Response	2	accepted	EID13303 A 54-year-old female with recurrent stage IV ACC that progressed after adrenalectomy, radiation, and mitotane had a TMB-high (11.6 mutations/Mb), MSS, PD-L1-negative tumor with a markedly clonal molec… (full text at CIViC) PMID 42158873 · Nakhleh et al., 2026 · Open in CIViC	civic
TP53 Mutation1
(prognostic)	Adrenal Cortical CarcinomaALIAS	Prognostic	B	Supports Poor Outcome	2	accepted	EID1028 TP53 mutation was shown to be associated with shorter overall survival in patients with adrenocortical tumors (log-rank test; P=0.098). Of 20 patients studied, 5 had coding mutation in TP53. Four of t… (full text at CIViC) PMID 15922892 · Sidhu et al., 2005 · Open in CIViC	civic

Data updated 19 minutes agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.