Subtype
Large Intestinal Neoplasm
CI-CAN-00001062Explore in graph →
Non-malignant1,847 active trials21 approved drugs383 evidence items
- NCIt
- C215201
Loading cancer entity…
Loading cancer entity…
Subtype
CI-CAN-00001062Explore in graph →
Clinical trials
8,849 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT01776307 | A Study of BBI608 in Adult Patients With Advanced Colorectal Cancer | completed | Phase 2 | 200 | Sumitomo Pharma America, Inc.INDUSTRY | 1 | Nov 15, 2023 | clinicaltrials |
| NCT00019760 | Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colorectal Cancer That is Metastatic to the Liver | completed | Phase 2 | — | National Institutes of Health Clinical Center (CC)NIH | 1 | Oct 31, 2023 |
| clinicaltrials |
| NCT03206073 | A Phase I/II Study of Pexa-Vec Oncolytic Virus in Combination With Immune Checkpoint Inhibition in Refractory Colorectal Cancer | completed | Phase 1 / Phase 2 | 34 | National Cancer Institute (NCI)NIH | 1 | Oct 24, 2023 | clinicaltrials |
| NCT03854799 | Immunotherapy In Locally Advanced Rectal Cancer(AVANA) | completed | Phase 2 | 101 | Gruppo Oncologico del Nord-OvestOTHER | 1 | Oct 19, 2023 | clinicaltrials |
| NCT02017704 | Chemoradiation or Brachytherapy for Rectal Cancer(CORRECT) | completed | Phase 2 | 9 | Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsOTHER | 1 | Oct 17, 2023 | clinicaltrials |
| NCT02090101 | Study Evaluating the Influence of LV5FU2 Bevacizumab Plus Anakinra Association on Metastatic Colorectal Cancer(IRAFU) | completed | Phase 2 | 32 | Centre Georges Francois LeclercOTHER | 1 | Oct 17, 2023 | clinicaltrials |
| NCT03721653 | FOLFOXIRI + Bev + Atezo vs FOLFOXIRI + Bev as First-line Treatment of Unresectable Metastatic Colorectal Cancer Patients(AtezoTRIBE) | completed | Phase 2 | 218 | Gruppo Oncologico del Nord-OvestOTHER | 1 | Oct 12, 2023 | clinicaltrials |
| NCT03639714 | A Study of a Personalized Neoantigen Cancer Vaccine | completed | Phase 1 / Phase 2 | 29 | Gritstone bio, Inc.INDUSTRY | 2 | Sep 13, 2023 | clinicaltrials |
| NCT03953235 | A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens | completed | Phase 1 / Phase 2 | 39 | Gritstone bio, Inc.INDUSTRY | 1 | Sep 13, 2023 | clinicaltrials |
| NCT03156036 | Preoperative CRT With Capecitabine ± Temozolomide in Patients With LARC | completed | Phase 2 | 64 | Asan Medical CenterOTHER | 1 | Sep 7, 2023 | clinicaltrials |
| NCT04166435 | TMZ + Olaparib for MGMT Hypermethylated Colorectal Cancer | completed | Phase 2 | 11 | Yale UniversityOTHER | 1 | Sep 6, 2023 | clinicaltrials |
| NCT01622543 | Reolysin in Combination With FOLFOX6 and Bevacizumab or FOLFOX6 and Bevacizumab Alone in Metastatic Colorectal Cancer | completed | Phase 2 | 109 | Canadian Cancer Trials GroupNETWORK | 1 | Aug 23, 2023 | clinicaltrials |
| NCT01591421 | P13Kinase Inhibitor BKM120 in Combination With Panitumumab in Metastatic/Advanced RAS-Wild Type Colorectal Cancer. | completed | Phase 1 / Phase 2 | 22 | Canadian Cancer Trials GroupNETWORK | 1 | Aug 4, 2023 | clinicaltrials |
| NCT03602079 | Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene | completed | Phase 1 / Phase 2 | 49 | Klus Pharma Inc.INDUSTRY | 1 | Aug 3, 2023 | clinicaltrials |
| NCT02460198 | Study of Pembrolizumab (MK-3475) as Monotherapy in Participants With Previously-Treated Locally Advanced Unresectable or Metastatic Colorectal Cancer (MK-3475-164/KEYNOTE-164) | completed | Phase 2 | 124 | Merck Sharp & Dohme LLCINDUSTRY | 0 | Jul 27, 2023 | clinicaltrials |
| NCT00578721 | Trial of Aspirin and Arginine Restriction in Colorectal Cancer | completed | Phase 2 | 24 | University of California, IrvineOTHER | 1 | Jul 7, 2023 | clinicaltrials |
| NCT03735680 | A Study to Evaluate ONM-100, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer | completed | Phase 2 | 30 | OncoNano Medicine, Inc.INDUSTRY | 1 | Jul 7, 2023 | clinicaltrials |
| NCT00098787 | Bevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal Cancer | completed | Phase 2 | 247 | Eastern Cooperative Oncology GroupNETWORK | 1 | Jul 5, 2023 | clinicaltrials |
| NCT05116891 | A Phase 1/2 Study of CAN04 in Combination With Different Chemotherapy Regimens in Subjects With Advanced Solid Tumors | completed | Phase 1 / Phase 2 | 40 | Cantargia ABINDUSTRY | 2 | Jul 3, 2023 | clinicaltrials |
| NCT00316888 | Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer | completed | Phase 2 | 63 | ECOG-ACRIN Cancer Research GroupNETWORK | 1 | Jun 29, 2023 | clinicaltrials |
| NCT03690921 | Linear Energy Transfer (LET)-Optimized Intensity Modulated Proton Therapy (IMPT) as a Component of Definitive Chemoradiation for Newly Diagnosed Squamous Cell Carcinoma of the Anal Canal: a Feasibility Trial | completed | Phase 2 | 8 | M.D. Anderson Cancer CenterOTHER | 1 | Jun 29, 2023 | clinicaltrials |
| NCT01079780 | Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After Treatment With Bevacizumab-Containing Chemotherapy | completed | Phase 2 | 136 | Eastern Cooperative Oncology GroupNETWORK | 1 | Jun 28, 2023 | clinicaltrials |
| NCT00002650 | High-Dose Folic Acid in Preventing Colorectal Cancer in Patients Who Have Had Polyps Surgically Removed | completed | Phase 2 | 80 | Eastern Cooperative Oncology GroupNETWORK | 1 | Jun 22, 2023 | clinicaltrials |
| NCT00002997 | Cryosurgery in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer | completed | Phase 2 | — | Eastern Cooperative Oncology GroupNETWORK | 1 | Jun 15, 2023 | clinicaltrials |
| NCT00004860 | Fluorouracil-Uracil and Leucovorin in Treating Elderly Patients With Metastatic Colorectal Cancer | completed | Phase 2 | — | Eastern Cooperative Oncology GroupNETWORK | 2 | Jun 15, 2023 | clinicaltrials |
| NCT01328171 | FOLFOXIRI With or Without Panitumumab in Metastatic Colorectal Cancer (VOLFI)(VOLFI) | completed | Phase 2 | 93 | AIO-Studien-gGmbHOTHER | 1 | Jun 15, 2023 | clinicaltrials |
| NCT01991873 | Maintenance Therapy With 5-FU/FA Plus Panitumumab vs. 5-FU/FA Alone After Prior Induction and Re-induction After Progress for 1st-line Treatment of Metastatic Colorectal Cancer(PanaMa) | completed | Phase 2 | 387 | AIO-Studien-gGmbHOTHER | 1 | Jun 15, 2023 | clinicaltrials |
| NCT03428126 | Study of Durvalumab (MEDI4736) (Anti-PD-L1) and Trametinib (MEKi) in MSS Metastatic Colon Cancer | completed | Phase 2 | 29 | M.D. Anderson Cancer CenterOTHER | 1 | Jun 15, 2023 | clinicaltrials |
| NCT02919969 | Pembrolizumab in Metastatic Anal Cancer | completed | Phase 2 | 38 | Dana-Farber Cancer InstituteOTHER | 1 | Jun 12, 2023 | clinicaltrials |
| NCT05025631 | A Phase II Study on Dose Optimization of Fruquintinib in Elderly mCRC Patients Refractory to Standard Treatment（DOFEMCRC）(DOFEMCRC) | completed | Phase 2 | 29 | Zhen-Yu DingOTHER | 1 | Apr 28, 2023 | clinicaltrials |
| NCT00093379 | Capecitabine, Oxaliplatin, and Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer | completed | Phase 2 | 20 | M.D. Anderson Cancer CenterOTHER | 1 | Apr 18, 2023 | clinicaltrials |
| NCT05816980 | Re-irradiation for Pelvic Recurrences in Rectal Cancer Patients(Re-RAD-I) | completed | Phase 2 | 16 | Aarhus University HospitalOTHER | 2 | Apr 18, 2023 | clinicaltrials |
| NCT03279289 | Study to Assess the Efficacy and Safety of Treatment With FOLFIRI-aflibercept Compared to Initial Treatment With FOLFIRI-aflibercept (for 6 Cycles) Followed by Maintenance With 5FU-aflibercept, in an Elderly Population With mCRC After Failure of an Oxaliplatin-based Regimen(AFEMA) | completed | Phase 2 | 170 | Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)OTHER | 1 | Apr 13, 2023 | clinicaltrials |
| NCT03427411 | M7824 in Subjects With HPV Associated Malignancies | completed | Phase 2 | 57 | National Cancer Institute (NCI)NIH | 1 | Mar 28, 2023 | clinicaltrials |
| NCT03770689 | Study of Peposertib in Combination With Capecitabine and RT in Rectal Cancer | completed | Phase 1 / Phase 2 | 19 | EMD Serono Research & Development Institute, Inc.INDUSTRY | 2 | Mar 21, 2023 | clinicaltrials |
| NCT03801915 | Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers | completed | Phase 2 | 10 | National Cancer Institute (NCI)NIH | 1 | Mar 21, 2023 | clinicaltrials |
| NCT02399813 | A Phase 2 Study of Axalimogene Filolisbac (ADXS11-001) in Participants With Carcinoma of the Anorectal Canal | completed | Phase 2 | 36 | Advaxis, Inc.INDUSTRY | 1 | Mar 20, 2023 | clinicaltrials |
| NCT03299660 | Avelumab With Chemoradiation in Locally Advanced Rectal Cancer | completed | Phase 2 | 37 | Peter MacCallum Cancer Centre, AustraliaOTHER | 1 | Mar 16, 2023 | clinicaltrials |
| NCT04224415 | Re-challenge of Anti-EGFR for Patients With RAS/BRAF Wild-type Metastatic CRC | completed | Phase 2 | 35 | Yuhong LiOTHER | 1 | Feb 15, 2023 | clinicaltrials |
| NCT03202758 | Evaluation of the Safety and the Tolerability of Durvalumab Plus Tremelimumab Combined With FOLFOX in mCRC(MEDITREME) | completed | Phase 1 / Phase 2 | 57 | Centre Georges Francois LeclercOTHER | 1 | Feb 10, 2023 | clinicaltrials |
| NCT03043729 | mFOLFOX6 vs. mFOLFOX6 + Aflibercept as Neoadjuvant Treatment in MRI-defined T3-rectal Cancer | completed | Phase 2 | 119 | AIO-Studien-gGmbHOTHER | 1 | Feb 6, 2023 | clinicaltrials |
| NCT04021589 | Chemotherapy w/wo WeiLeShu in Metastatic Colorectal Cancer | completed | Phase 2 | 40 | Zhejiang UniversityOTHER | 1 | Jan 30, 2023 | clinicaltrials |
| NCT02713529 | Safety and Efficacy Study of AMG 820 and Pembrolizumab Combination in Select Advanced Solid Tumor Cancer | completed | Phase 1 / Phase 2 | 117 | AmMax Bio, Inc.INDUSTRY | 6 | Jan 20, 2023 | clinicaltrials |
| NCT03477019 | Ultrasound-enhanced Delivery of Chemotherapy to Patients With Liver Metastasis From Breast- and Colorectal Cancer | completed | Phase 1 / Phase 2 | 17 | St. Olavs HospitalOTHER | 1 | Jan 19, 2023 | clinicaltrials |
| NCT03458975 | Targeted Delivery of Chemotherapy With Ultrasound and Microbublles(SONCHIMIO) | completed | Phase 2 | 7 | University Hospital, ToursOTHER | 1 | Jan 9, 2023 | clinicaltrials |
| NCT02963831 | A Study to Investigate ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies | completed | Phase 1 / Phase 2 | 67 | Ludwig Institute for Cancer ResearchOTHER | 1 | Dec 22, 2022 | clinicaltrials |
| NCT04009876 | A Study to Evaluate a Chemotherapy Treatment Followed by Chemo and Radiotherapy in Patients With Rectal Cancer | completed | Phase 2 | 30 | Fundación de investigación HMOTHER | 1 | Dec 13, 2022 | clinicaltrials |
| NCT04591379 | Intratumoral Influenza Vaccine for Early Colorectal Cancer | completed | Phase 2 | 10 | Zealand University HospitalOTHER | 1 | Dec 13, 2022 | clinicaltrials |
Data updated 23 days agoSource updated Nov 15, 2023source: clinicaltrials