Embryonal Tumor with Multilayered Rosettes — Variants & evidence

Embryonal Tumor with Multilayered Rosettes — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

3 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items (1 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Amplification1
(diagnostic)	Embryonal Tumor with Multilayered Rosettes, C19MC-Altered	Diagnostic	A	Supports Positive	5	accepted	EID12389 This landmark study contributed to the recognition of embryonal tumor with multilayered rosettes (ETMRs) as a distinct entity in the 2016 WHO classification. Previously, ETMRs were included within the… (full text at CIViC) PMID 19962671 · Li et al., 2009 · Open in CIViC	civic
TTYH1::C19MC fusion1
(diagnostic)	Embryonal Tumor with Multilayered Rosettes	Diagnostic	A	Supports Positive	5	accepted	EID12390 This study aimed to identify the mechanism underlying overexpression of a miRNA cluster on chromosome 19q13.4 (C19MC) and its oncogenicity in embryonal tumors with multilayered rosettes (ETMRs). Throu… (full text at CIViC) PMID 24316981 · Kleinman et al., 2014 · Open in CIViC	civic
v::C19MC fusion1
(diagnostic)	Embryonal Tumor with Multilayered Rosettes	Diagnostic	A	Supports Positive	5	accepted	EID12391 This cohort study examined the molecular landscape of embryonal tumors with multilayered rosettes (ETMRs) at diagnosis and relapse. ETMRs have previously been shown to frequently (~90%) exhibit amplif… (full text at CIViC) PMID 31802000 · Lambo et al., 2019 · Open in CIViC	civic

Data updated 6 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.