Chronic Neutrophilic Leukemia — Variants & evidence

Chronic Neutrophilic Leukemia — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

3 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CSF3R Mutation1
(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID1388 Study found that mutations in CSF3R are enriched in patients with Chronic Neutrophilic Leukemia (CNL) or Atypical Chronic Myeloid Leukemia (16/27, 59%) when compared to other blood disorders (AML=1/29… (full text at CIViC) PMID 23656643 · Maxson et al., 2013 · Open in CIViC	civic
CSF3R T618I2
Ruxolitinib	Predictive	C	Supports Sensitivity Response	4	accepted	EID6381 Case report of a patient treated with ruxolitinib, an FDA-approved JAK1/2 inhibitor, which resulted in dramatic improvement of his blood counts. He also had significant reduction of spleen volume and … (full text at CIViC) PMID 25180155 · Dao et al., 2014 · Open in CIViC	civic
〃	Predictive	D	Supports Sensitivity Response	4	accepted	EID6380 Demonstrates that activating mutations in CSF3R are sufficient to drive a myeloproliferative disorder resembling aCML and CNL that is sensitive to pharmacologic JAK inhibition. PMID 24081659 · Fleischman et al., 2013 · Open in CIViC	civic

Data updated 10 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.