Childhood Ependymoma — Variants & evidence

Childhood Ependymoma — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

5 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items (3 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ERBB2 Amplification1
Lapatinib	Childhood Ependymoma	Predictive	B	Supports Sensitivity Response	1	accepted	EID9778 From a phase one clinical trial, pediatric patients with refractory CNS malignancies were administered 300-1150 mg/m2 twice daily of ERBB2 and EGFR inhibitor lapatinib. The maximum-tolerated dose was … (full text at CIViC) PMID 20713864 · Fouladi et al., 2010 · Open in CIViC	civic
EGFR Fusion1
Gefitinib	Childhood Ependymoma	Predictive	A	Supports Sensitivity Response	1	submitted	EID10933 SEC61G::EGFR (5'UTR::e14) (5'-UTR of SEC61G and 3'-UTR of EGFR) was detected in ependymoma as a change sensitive to gefitinib (also confirmed by mice xenografts model). Screening of 16 ependymoma pati… (full text at CIViC) PMID 29092923 · Servidei et al., 2017 · Open in CIViC	civic
MAMLD1 Fusion1
(diagnostic)	Supratentorial Ependymoma YAP1 Fusion-Positive	Diagnostic	B	Supports Positive	4	accepted	EID11888 A total of 15 pediatric patients with supratentorial ependymomas harboring YAP1::MAMLD1 fusions were reported. In all 15 cases, YAP1::MAMLD1 fusions were confirmed by RT-PCR and sequencing. In the ma… (full text at CIViC) PMID 30246434 · Andreiuolo et al., 2019 · Open in CIViC	civic
SIRAL1 Fusion1
(diagnostic)	Supratentorial Ependymoma YAP1 Fusion-Positive	Diagnostic	C	Supports Positive	1	accepted	EID11889 This is a case report of a 26-year-old male patient who sufferred 3 grand mal seizures and was found to have a left frontal lobe ependymoma with a YAP1::FAM118B fusion. No other genetic alterations we… (full text at CIViC) PMID 33480048 · Wang et al., 2021 · Open in CIViC	civic
YAP1 Fusion1
(diagnostic)	Supratentorial Ependymoma YAP1 Fusion-Positive	Diagnostic	B	Supports Positive	4	accepted	EID11890 DNA methylation profiling of 500 ependymal tumors identified 9 molecular profiles with 3 occurring in the supratentorial compartment (designated ST EPN). RNA sequencing performed in 7 of the 13 cases… (full text at CIViC) PMID 25965575 · Pajtler et al., 2015 · Open in CIViC	civic

Data updated 22 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.