Benign Osteogenic Neoplasm — Variants & evidence

Benign Osteogenic Neoplasm — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

4 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items (4 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FOSB Rearrangement2
(diagnostic)	Osteoblastoma	Diagnostic	C	Supports Positive	2	rejected	EID11597 Whole-genome DNA and RNA sequencing in 5 osteoblastomas and 1 osteoid osteoma identified FOS rearrangements in 5 tumors (4 osteoblastoma and 1 osteoid osteoma) and a FOSB rearrangement in 1 osteoblast… (full text at CIViC) PMID 29858576 · Fittall et al., 2018 · Open in CIViC	civic
〃	Osteoblastoma	Diagnostic	C	Supports Positive	2	accepted	EID11787 This study investigated two cases of osteoblastoma to identify genetic aberrations using cytogenetic analysis, RNA sequencing, and molecular analyses. In the first case, a FOS::ANKH fusion transcript… (full text at CIViC) PMID 32108038 · Panagopoulos et al., 2020 · Open in CIViC	civic
FOS Rearrangement2
(diagnostic)	Osteoblastoma	Diagnostic	B	Supports Positive	4	accepted	EID11596 Whole-genome DNA and RNA sequencing of 5 osteoblastomas and 1 osteoid osteoma identified FOS rearrangements in 5 tumors (4 osteoblastomas and 1 osteoid osteoma) and a FOSB rearrangement in 1 osteoblas… (full text at CIViC) PMID 29858576 · Fittall et al., 2018 · Open in CIViC	civic
〃	Osteoblastoma	Diagnostic	B	Supports Positive	3	accepted	EID11786 The study evaluated FOS and FOSB immunohistochemistry (IHC) in osteoid osteoma (n=23), osteoblastoma (n=22), and other bone tumor types to gauge the specificity of FOS/FOSB IHC for diagnosing these tu… (full text at CIViC) PMID 31768625 · Lam et al., 2020 · Open in CIViC	civic

Data updated 7 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.