Hematologic Malignancy
B Lymphoblastic Leukemia/Lymphoma
CI-CAN-00000469Explore in graph →
Hematologic163 active trials1 approved drugs180 evidence items
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Hematologic Malignancy
CI-CAN-00000469Explore in graph →
Variants & evidence
296 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PAX5 P80R2 | ||||||||
| (diagnostic) | B Acute Lymphoblastic Leukemia with PAX5 P80R MutationALIAS | Diagnostic | B | Supports Positive | 3 | accepted | EID7291Integrated genomic analysis was performed for 1,988 childhood and adult B-ALL cases. Forty four cases (2.2%) showed the P80R substitution in the DNA binding domain for the PAX5 transcription factor ge… (full text at CIViC) PMID 30643249 · Gu et al., 2019 · Open in CIViC | civic |
| (oncogenic) | B Acute Lymphoblastic Leukemia with PAX5 P80R MutationALIAS | Oncogenic | D | Supports Oncogenicity | 4 | submitted | EID11522To examine the effects of PAX5 P80R on B cell maturation, PAX5 WT, P80R, V26G, and P34Q were expressed in Pax5 depleted bone marrow cells. While PAX5 V26G and PAX5 P34Q could rescue B cell differentia… (full text at CIViC) PMID 30643249 · Gu et al., 2019 · Open in CIViC | civic |
| JAK2 Fusion1 | ||||||||
| (diagnostic) | B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like | Diagnostic | C | Supports Positive | 3 | accepted | EID7704The PCM1-JAK2 fusion is typically associated with 'myeloid/lymphoid neoplasms with eosinophilia and gene rearrangements', which is a specific disease entity according to WHO classification. However, i… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| JAK2 Fusion2 | ||||||||
| (diagnostic) | B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like | Diagnostic | C | Supports Positive | 3 | accepted | EID7673In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| 〃 | B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like | Diagnostic | C | Supports Positive | 3 | accepted | EID8099In B-lymphoblastic leukemia/lymphoma (B-ALL), the presence of this fusion is associated with so-called BCR/ABL1 like (Ph-like) subtype of the disease.The PPFIBP1-JAK2 fusion is rare; In this study inv… (full text at CIViC) PMID 27870571 · Roberts et al., 2017 · Open in CIViC | civic |
| PRPS1 A190T4 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID7888PRPS1 exons were sequenced in the diagnosis and relapse samples of 358 B-Cell Childhood Acute Lymphoblastic Leukemia relapse patients (138 Chinese and 220 German). PRPS1 A190T was detected only at rel… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Lometrexol + MercaptopurineCombination | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID7913Treatment with the GART inhibitor, Lometrexol (de novo purine synthesis inhibitor), sensitized Reh cells overexpressing PRPS1 A190T to mercaptopurine (6-MP) as evidenced by significant reduction of th… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Mercaptopurine | ||||||||
| PRPS1 A190V2 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | C | Supports Poor Outcome | 3 | submitted | EID7887PRPS1 exons were sequenced in the diagnosis and relapse samples of 358 B-Cell Childhood Acute Lymphoblastic Leukemia relapse patients (138 Chinese and 220 German). PRPS1 A190V was detected only at rel… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Supports Resistance | 4 | submitted | EID7908Lentiviral-mediated overexpression of PRPS1 A190V in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| PRPS1 A87T1 | ||||||||
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Does Not Support Resistance | 4 | accepted | EID7919Lentiviral-mediated overexpression of PRPS1 A87T in Reh cells resulted in similar cytotoxic response (IC50 and apoptosis %) compared to controls (empty vector and wildtype PRPS1 overexpression) after … (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| PRPS1 C77S1 | ||||||||
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Does Not Support Resistance | 3 | accepted | EID7916Lentiviral-mediated overexpression of PRPS1 C77S in Reh cells resulted in similar cytotoxic response to controls (empty vector and overexpression of known reduced-function PRPS1 mutants) after exposur… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| PRPS1 D139G1 | ||||||||
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Does Not Support Resistance | 3 | accepted | EID7915Lentiviral-mediated overexpression of PRPS1 D139G in Reh cells resulted in similar cytotoxic response to controls (empty vector and overexpression of known reduced-function PRPS1 mutants) after exposu… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| PRPS1 D183E3 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | C | Supports Poor Outcome | 3 | submitted | EID7879PRPS1 exons were sequenced in the diagnosis and relapse samples of 358 B-Cell Childhood Acute Lymphoblastic Leukemia relapse patients (138 Chinese and 220 German). PRPS1 D183E was detected only at rel… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Supports Resistance | 4 | accepted | EID7900Lentiviral-mediated overexpression of PRPS1 D183E in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Asparaginase | ||||||||
| PRPS1 D183H1 | ||||||||
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Supports Resistance | 4 | submitted | EID7897Lentiviral-mediated overexpression of D183H in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apoptosis co… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| PRPS1 G174E2 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | C | Supports Poor Outcome | 3 | submitted | EID7881PRPS1 exons were sequenced in the diagnosis and relapse samples of 358 B-Cell Childhood Acute Lymphoblastic Leukemia relapse patients (138 Chinese and 220 German). PRPS1 G174E was detected only at rel… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Supports Resistance | 4 | submitted | EID7902Lentiviral-mediated overexpression of PRPS1 G174E in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| PRPS1 I72V1 | ||||||||
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Does Not Support Resistance | 3 | accepted | EID7917Lentiviral-mediated overexpression of PRPS1 I72V in Reh cells resulted in similar cytotoxic response to controls (empty vector and overexpression of known reduced-function PRPS1 mutants) after exposur… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| PRPS1 K176N3 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | C | Supports Poor Outcome | 3 | submitted | EID7880PRPS1 exons were sequenced in the diagnosis and relapse samples of 358 B-Cell Childhood Acute Lymphoblastic Leukemia relapse patients (138 Chinese and 220 German). PRPS1 K176N was detected only at rel… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Supports Resistance | 4 | accepted | EID7901Lentiviral-mediated overexpression of PRPS1 K176N in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Asparaginase | ||||||||
| PRPS1 L191F4 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | C | Supports Poor Outcome | 3 | submitted | EID7878PRPS1 exons were sequenced in the diagnosis and relapse samples of 358 B-Cell Childhood Acute Lymphoblastic Leukemia relapse patients (138 Chinese and 220 German). PRPS1 L191F was detected only at rel… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Cytarabine | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID7911Lentiviral-mediated overexpression of PRPS1 L191F in Reh cells resulted in sensitivity to cytarabine (Ara-C) treatment as indicated by reduced cell viability and IC50 compared to empty vector and wild… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Mercaptopurine + ThioguanineSubstitutes | ||||||||
| PRPS1 M115T1 | ||||||||
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Does Not Support Resistance | 4 | accepted | EID7920Lentiviral-mediated overexpression of PRPS1 M115T in Reh cells resulted in similar cytotoxic response (IC50 and apoptosis %) compared to controls (empty vector and wildtype PRPS1 overexpression) after… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| PRPS1 MUTATION1 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | B | Supports Poor Outcome | 4 | accepted | EID7871Sequencing revealed relapse specific PRPS1 mutations in 24/358 (6.7%) relapsed childhood B-ALL cases derived from multiple cohorts. In the Chinese cohort, 18/138 (13%) cases harbored relapse specific … (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| PRPS1 N114D2 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | C | Supports Poor Outcome | 3 | submitted | EID7883PRPS1 exons were sequenced in the diagnosis and relapse samples of 358 B-Cell Childhood Acute Lymphoblastic Leukemia relapse patients (138 Chinese and 220 German). PRPS1 N114D was detected only at rel… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Supports Resistance | 4 | submitted | EID7904Lentiviral-mediated overexpression of PRPS1 N114D in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| PRPS1 N144S4 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | C | Supports Poor Outcome | 3 | submitted | EID7882PRPS1 exons were sequenced in the diagnosis and relapse samples of 358 B-Cell Childhood Acute Lymphoblastic Leukemia relapse patients (138 Chinese and 220 German). PRPS1 N144S was detected only at rel… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Cytarabine | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID7910Lentiviral-mediated overexpression of PRPS1 N144S in Reh cells resulted in sensitivity to cytarabine (Ara-C) treatment as indicated by reduced cell viability and IC50 compared to empty vector and wild… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Mercaptopurine + ThioguanineSubstitutes | ||||||||
| PRPS1 S103I2 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | C | Supports Poor Outcome | 3 | submitted | EID7884PRPS1 exons were sequenced in the diagnosis and relapse samples of 358 B-Cell Childhood Acute Lymphoblastic Leukemia relapse patients (138 Chinese and 220 German). PRPS1 S103I was detected only at rel… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Supports Resistance | 4 | accepted | EID7905Lentiviral-mediated overexpression of PRPS1 S103I in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| PRPS1 S103N3 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | C | Supports Poor Outcome | 3 | submitted | EID7885PRPS1 exons were sequenced in the diagnosis and relapse samples of 358 B-Cell Childhood Acute Lymphoblastic Leukemia relapse patients (138 Chinese and 220 German). PRPS1 S103N was detected only at rel… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Supports Resistance | 4 | accepted | EID7906Lentiviral-mediated overexpression of PRPS1 S103N in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Asparaginase | ||||||||
| PRPS1 S103T4 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | C | Supports Poor Outcome | 3 | submitted | EID7886PRPS1 exons were sequenced in the diagnosis and relapse samples of 358 B-Cell Childhood Acute Lymphoblastic Leukemia relapse patients (138 Chinese and 220 German). PRPS1 S103T was detected only at rel… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Lometrexol + MercaptopurineCombination | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Supports Sensitivity Response | 3 | submitted | EID7912Treatment with the GART inhibitor, Lometrexol (de novo purine synthesis inhibitor), sensitized Reh cells overexpressing PRPS1 S103T to 6-MP as evidenced by significant reduction of the cell line's 6-M… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Mercaptopurine | ||||||||
| PRPS1 T303S3 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | C | Supports Poor Outcome | 3 | submitted | EID7877PRPS1 exons were sequenced in the diagnosis and relapse samples of 358 B-Cell Childhood Acute Lymphoblastic Leukemia relapse patients (138 Chinese and 220 German). PRPS1 T303S was detected only at rel… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Supports Resistance | 4 | accepted | EID7898Lentiviral-mediated overexpression of PRPS1 T303S in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| Asparaginase | ||||||||
| PRPS1 V53A1 | ||||||||
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Does Not Support Resistance | 3 | accepted | EID7918Lentiviral-mediated overexpression of PRPS1 V53A in Reh cells resulted in similar cytotoxic response to controls (empty vector and overexpression of known reduced-function PRPS1 mutants) after exposur… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| PRPS1 Y311C1 | ||||||||
| Mercaptopurine + ThioguanineSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Does Not Support Resistance | 3 | submitted | EID7914Lentiviral-mediated overexpression of PRPS1 Y311C in Reh cells resulted in similar cytotoxic response to controls (empty vector and overexpression of known reduced-function PRPS1 mutants) after exposu… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
Data updated 1 hour agoSource updated unknownsource: civic (CC0)
Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.
| B Lymphoblastic Leukemia/LymphomaCURATED_BROADER |
| Predictive |
| D |
| Supports Resistance |
| 5 |
| accepted |
EID7909Lentiviral-mediated overexpression of PRPS1 A190T in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC |
| civic |
| Asparaginase + Cytarabine + Daunorubicin + MethotrexateSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Does Not Support Resistance | 3 | accepted | EID7928Lentiviral-mediated overexpression of PRPS1 A190T in Reh cells resulted no difference in response to Methotrexate, Cytarabine, Daunorubicin, or L-Asparginase compared to empty vector and wildtype PRPS… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| B Lymphoblastic Leukemia/LymphomaCURATED_BROADER |
| Predictive |
| D |
| Does Not Support Resistance |
| 3 |
| accepted |
EID7927Lentiviral-mediated overexpression of PRPS1 D183E in Reh cells resulted no difference in response to Methotrexate, Cytarabine, Daunorubicin, or L-Asparginase compared to empty vector and wildtype PRPS… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC |
| civic |
| B Lymphoblastic Leukemia/LymphomaCURATED_BROADER |
| Predictive |
| D |
| Does Not Support Resistance |
| 3 |
| accepted |
EID7926Lentiviral-mediated overexpression of PRPS1 K176N in Reh cells resulted no difference in response to Methotrexate, Cytarabine, Daunorubicin, or L-Asparginase compared to empty vector and wildtype PRPS… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC |
| civic |
| B Lymphoblastic Leukemia/LymphomaCURATED_BROADER |
| Predictive |
| D |
| Supports Resistance |
| 4 |
| accepted |
EID7899Lentiviral-mediated overexpression of PRPS1 L191F in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC |
| civic |
| Asparaginase + Daunorubicin + MethotrexateSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Does Not Support Resistance | 3 | accepted | EID7923Lentiviral-mediated overexpression of PRPS1 L191F in Reh cells resulted no difference in response to Methotrexate, Daunorubicin, or L-Asparginase compared to empty vector and wildtype PRPS1 overexpres… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| B Lymphoblastic Leukemia/LymphomaCURATED_BROADER |
| Predictive |
| D |
| Supports Resistance |
| 4 |
| accepted |
EID7903Lentiviral-mediated overexpression of PRPS1 N144S in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC |
| civic |
| Asparaginase + Daunorubicin + MethotrexateSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Does Not Support Resistance | 3 | accepted | EID7930Lentiviral-mediated overexpression of PRPS1 N144S in Reh cells resulted no difference in response to Methotrexate, Daunorubicin, or L-Asparginase compared to empty vector and wildtype PRPS1 overexpres… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| B Lymphoblastic Leukemia/LymphomaCURATED_BROADER |
| Predictive |
| D |
| Does Not Support Resistance |
| 3 |
| accepted |
EID7925Lentiviral-mediated overexpression of PRPS1 S103N in Reh cells resulted no difference in response to Methotrexate, Cytarabine, Daunorubicin, or L-Asparginase compared to empty vector and wildtype PRPS… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC |
| civic |
| B Lymphoblastic Leukemia/LymphomaCURATED_BROADER |
| Predictive |
| D |
| Supports Resistance |
| 5 |
| accepted |
EID7907Lentiviral-mediated overexpression of PRPS1 S103T in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC |
| civic |
| Asparaginase + Cytarabine + Daunorubicin + MethotrexateSubstitutes | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | D | Does Not Support Resistance | 3 | accepted | EID7924Lentiviral-mediated overexpression of PRPS1 S103T in Reh cells resulted no difference in response to Methotrexate, Cytarabine, Daunorubicin, or L-Asparginase compared to empty vector and wildtype PRPS… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC | civic |
| B Lymphoblastic Leukemia/LymphomaCURATED_BROADER |
| Predictive |
| D |
| Does Not Support Resistance |
| 3 |
| accepted |
EID7929Lentiviral-mediated overexpression of PRPS1 T303S in Reh cells resulted no difference in response to Methotrexate, Cytarabine, Daunorubicin, or L-Asparginase compared to empty vector and wildtype PRPS… (full text at CIViC) PMID 25962120 · Li et al., 2015 · Open in CIViC |
| civic |