Adamantinomatous Craniopharyngioma — Variants & evidence

Adamantinomatous Craniopharyngioma — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

3 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CTNNB1 Exon 3 Mutation3
(diagnostic)	Diagnostic	B	Supports Positive	4	submitted	EID12111 Assessment of beta-catenin mutations in a large collections of pituitary adenomas (n=60) and craniopharynangiomas (n=41), identified CTNNB1 exon 3 mutations in 77% of craniopharynangiomas, all of the … (full text at CIViC) PMID 15891929 · Buslei et al., 2005 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	submitted	EID12112 Whole-exome sequencing identified CTNNB1 mutations in 11 of 12 (92%) of adamantinomatous craniopharyngiomas examined. No other recurrent mutations or genomic aberrations were identified. Targeted se… (full text at CIViC) PMID 24413733 · Brastianos et al., 2014 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	submitted	EID12113 CTNNB1 sequencing a cohort of 80 adamantinomatous craniopharyngiomas and 35 papillary craniopharyngiomas identified CTNNB1 activating mutations exclusively in the adamantinomatous subtype (in 79 or 8… (full text at CIViC) PMID 26927026 · Hölsken et al., 2016 · Open in CIViC	civic

Data updated 22 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.