TFE3 Fusion

CI-VAR-00001378Explore in graph →CIViC 4577

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Epithelioid Hemangioendothelioma4unmapped disease
YAP1::TFE3 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID11536 This study by Antonescu, et al. (2013) included 10 cases with a diagnosis of epithelioid hemangioendothelioma (EHE), which showed unusual morphologic features such as abundant eosinophilic cytoplasm, … (full text at CIViC) PMID 23737213 · Antonescu et al., 2013 · Open in CIViC	civic
YAP1::TFE3 Fusion	(oncogenic)	Oncogenic	B	Supports Oncogenicity	2	accepted	EID11538 This 2021 paper by Dermawan, et al. included 24 cases of YAP1::TFE3 fusion-positive epithelioid hemangioendotheliomas (EHE), with an age range of 20 to 78 years old. All cases were confirmed by molecu… (full text at CIViC) PMID 34381186 · Dermawan et al., 2021 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.