VHL Y156_T157del (c.465_470del)

CI-VAR-00004762Explore in graph →NP_000542.1:p.Tyr156_Thr157delNM_000551.3:c.465_470delCIViC 2453

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Von Hippel-Lindau Disease2unmapped disease
VHL Y156_T157del (c.465_470del)	(predisposing)	Predisposing	C	Supports Uncertain Significance	1	submitted	EID6580 A prospective study followed 128 participants affected by VHL syndrome for 12 years in Padova, Italy. Individual patient data was not available, but frequency of specific mutations was presented. This… (full text at CIViC) PMID 26763786 · Feletti et al., 2016 · Open in CIViC	civic
VHL Y156_T157del (c.465_470del)	(predisposing)	Predisposing	C	N/A N/A	3	submitted	EID8695 426 unrelated subjects with a clinical diagnosis ranging from VHL syndrome to sporadic potentially VHL-related tumours were analyzed for mutation in the VHL gene. The analysis was carried out by the V… (full text at CIViC) PMID 21463266 · Leonardi et al., 2011 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.